About: Roscovitine-based CDK inhibitors acting as N-donor ligands in the platinum(II) oxalato complexes: Preparation, characterization and in vitro cytotoxicity

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About: Roscovitine-based CDK inhibitors acting as N-donor ligands in the platinum(II) oxalato complexes: Preparation, characterization and in vitro cytotoxicity Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The reactions of potassium bis(oxalato)platinate dihydrate with two molar equivalents of the potent adenine-based cyclin-dependent kinase inhibitor 2-(1-ethyl-2-hydroxyethylamino)-N6-(benzyl)-9-isopropyladenine (Roscovitine: Ros) and its benzyl-substituted analogues were performed and the [Pt(ox)(Ros)(2)] 3/4 H2O (1), [Pt(ox)(2OMeRos)(2)] H2O (2), (Pt(ox)(3OMeR-os)(2)] 1/2H(2)O (3) and [Pt(ox)(4OMeRos)(2)] 3/4 H2O (4) platinum(II) oxalato complexes were obtained. In vitro cytotoxic activity of the complexes against ovarian carcinoma (A2780), cisplatin resistant ovarian carcinoma (A2780cis). malignant melanoma (G-361), lung carcinoma (A549). cervix epitheloid carcinoma (HeLa). breast adenocarcinoma (MCF7) and osteosarcoma (HOS) human cancer cell lines was evaluated. The reactions of potassium bis(oxalato)platinate dihydrate with two molar equivalents of the potent adenine-based cyclin-dependent kinase inhibitor 2-(1-ethyl-2-hydroxyethylamino)-N6-(benzyl)-9-isopropyladenine (Roscovitine: Ros) and its benzyl-substituted analogues were performed and the [Pt(ox)(Ros)(2)] 3/4 H2O (1), [Pt(ox)(2OMeRos)(2)] H2O (2), (Pt(ox)(3OMeR-os)(2)] 1/2H(2)O (3) and [Pt(ox)(4OMeRos)(2)] 3/4 H2O (4) platinum(II) oxalato complexes were obtained. In vitro cytotoxic activity of the complexes against ovarian carcinoma (A2780), cisplatin resistant ovarian carcinoma (A2780cis). malignant melanoma (G-361), lung carcinoma (A549). cervix epitheloid carcinoma (HeLa). breast adenocarcinoma (MCF7) and osteosarcoma (HOS) human cancer cell lines was evaluated. (en)
Title	Roscovitine-based CDK inhibitors acting as N-donor ligands in the platinum(II) oxalato complexes: Preparation, characterization and in vitro cytotoxicity Roscovitine-based CDK inhibitors acting as N-donor ligands in the platinum(II) oxalato complexes: Preparation, characterization and in vitro cytotoxicity (en)
skos:prefLabel	Roscovitine-based CDK inhibitors acting as N-donor ligands in the platinum(II) oxalato complexes: Preparation, characterization and in vitro cytotoxicity Roscovitine-based CDK inhibitors acting as N-donor ligands in the platinum(II) oxalato complexes: Preparation, characterization and in vitro cytotoxicity (en)
skos:notation	RIV/61989592:15310/10:10213187!RIV11-MSM-15310___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM6198959218)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Trávníček, Zdeněk Popa, Igor Vrzal, Radim Dvořák, Zdeněk Štarha, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	285850
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/10:10213187
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Multinuclear NMR; CDK inhibitors; Cytotoxicity; Oxalate; Platinum(II) complexes (en)
http://linked.open.../riv/klicoveSlovo	Cytotoxicity Multinuclear NMR Platinum(II) complexes Oxalate CDK inhibitors
http://linked.open...odStatuVydavatele	FR - Francouzská republika
http://linked.open...ontrolniKodProRIV	[A2E72D068F90]
http://linked.open...i/riv/nazevZdroje	European Journal of Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	CA
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	45
http://linked.open...iv/tvurceVysledku	Dvořák, Zdeněk Trávníček, Zdeněk Vrzal, Radim Štarha, Pavel Popa, Igor
http://linked.open...ain/vavai/riv/wos	000282112700024
http://linked.open...n/vavai/riv/zamer	Komplexní sloučeniny a oxidy přechodných kovů s využitím v bioaplikacích a nanotechnologiích
issn	0223-5234
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

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