About: Novel pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy     Goto   Sponge   Distinct   Permalink

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  • The invention relates to 3-,5-,7-trisubstituted pyrazolo(4,3-d)pyrimidines represented by the general formula (I), and substituted alkyl, cycloalkyl, cycloheteroalkyl, cycloalkyl, alkyl, aryl or alkylaryl group, R5 is halogen, -NHNH2, -NHOH, NHCONH2, guanylo (NH-C(NH)NH2) an optionally substituted C1-C6 alkyl, alkenyl, alkinyl, C3-C15 cycloalkyl, Rf (C3-C15 cycloalkyl), heterocycle, heteroalkyl, aryl, heteroaryl, arylalkyl, cycloheteroalkyl, cycloheteroalkyl alkyl, heteroarylalkyl group etc.This invention relates to new pyrazolo(4,3-d)pyrimidine derivatives and to their use in suitable utilities, especially diagnostic and therapeutic methods. More specifically, the present invention also relates to the use of 3,5,7-trisubstituted pyrazolo(4,3-d)pyrimidines or a pharmaceutically acceptable salt thereof in combination with cytostatics in the preparation of a medicament for treating cancer.
  • The invention relates to 3-,5-,7-trisubstituted pyrazolo(4,3-d)pyrimidines represented by the general formula (I), and substituted alkyl, cycloalkyl, cycloheteroalkyl, cycloalkyl, alkyl, aryl or alkylaryl group, R5 is halogen, -NHNH2, -NHOH, NHCONH2, guanylo (NH-C(NH)NH2) an optionally substituted C1-C6 alkyl, alkenyl, alkinyl, C3-C15 cycloalkyl, Rf (C3-C15 cycloalkyl), heterocycle, heteroalkyl, aryl, heteroaryl, arylalkyl, cycloheteroalkyl, cycloheteroalkyl alkyl, heteroarylalkyl group etc.This invention relates to new pyrazolo(4,3-d)pyrimidine derivatives and to their use in suitable utilities, especially diagnostic and therapeutic methods. More specifically, the present invention also relates to the use of 3,5,7-trisubstituted pyrazolo(4,3-d)pyrimidines or a pharmaceutically acceptable salt thereof in combination with cytostatics in the preparation of a medicament for treating cancer. (en)
Title
  • Novel pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy
  • Novel pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy (en)
skos:prefLabel
  • Novel pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy
  • Novel pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy (en)
skos:notation
  • RIV/61989592:15310/10:10212652!RIV11-GA0-15310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA301/08/1649), P(GA522/09/1576), Z(AV0Z5038910)
http://linked.open...cisloPatentuVzoru
  • CA2480409
http://linked.open...eleniPatentuVzoru
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 275450
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15310/10:10212652
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • novel, pyrazolo[4,3-D]pyrimidines, process, preparation, method, therapy (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [E4138C0AA5E8]
http://linked.open.../licencniPoplatek
http://linked.open...ydaniPatentuVzoru
  • Gatineau
http://linked.open...atelePatentuVzoru
  • Canadian Intellectual Property Office (CIPO) Industry Canada
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...ydaniPatentuVzoru
http://linked.open...iv/tvurceVysledku
  • Kryštof, Vladimír
  • Strnad, Miroslav
  • Lenobel, René
  • HAVLÍČEK, Libor
  • Moravcová, Daniela
http://linked.open...mniOchranaPatentu
http://linked.open...avai/riv/vlastnik
http://linked.open...itiJinymSubjektem
http://linked.open...uzitiPatentuVzoru
http://linked.open...n/vavai/riv/zamer
http://linked.open...stnikPatentuVzoru
  • Univerzita Palackého v Olomouci a Ústav Experimentální Botaniky AV ČR v Praze
http://localhost/t...ganizacniJednotka
  • 15310
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