About: Novel pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The invention relates to 3-,5-,7-trisubstituted pyrazolo(4,3-d)pyrimidines represented by the general formula (I), and substituted alkyl, cycloalkyl, cycloheteroalkyl, cycloalkyl, alkyl, aryl or alkylaryl group, R5 is halogen, -NHNH2, -NHOH, NHCONH2, guanylo (NH-C(NH)NH2) an optionally substituted C1-C6 alkyl, alkenyl, alkinyl, C3-C15 cycloalkyl, Rf (C3-C15 cycloalkyl), heterocycle, heteroalkyl, aryl, heteroaryl, arylalkyl, cycloheteroalkyl, cycloheteroalkyl alkyl, heteroarylalkyl group etc.This invention relates to new pyrazolo(4,3-d)pyrimidine derivatives and to their use in suitable utilities, especially diagnostic and therapeutic methods. More specifically, the present invention also relates to the use of 3,5,7-trisubstituted pyrazolo(4,3-d)pyrimidines or a pharmaceutically acceptable salt thereof in combination with cytostatics in the preparation of a medicament for treating cancer. The invention relates to 3-,5-,7-trisubstituted pyrazolo(4,3-d)pyrimidines represented by the general formula (I), and substituted alkyl, cycloalkyl, cycloheteroalkyl, cycloalkyl, alkyl, aryl or alkylaryl group, R5 is halogen, -NHNH2, -NHOH, NHCONH2, guanylo (NH-C(NH)NH2) an optionally substituted C1-C6 alkyl, alkenyl, alkinyl, C3-C15 cycloalkyl, Rf (C3-C15 cycloalkyl), heterocycle, heteroalkyl, aryl, heteroaryl, arylalkyl, cycloheteroalkyl, cycloheteroalkyl alkyl, heteroarylalkyl group etc.This invention relates to new pyrazolo(4,3-d)pyrimidine derivatives and to their use in suitable utilities, especially diagnostic and therapeutic methods. More specifically, the present invention also relates to the use of 3,5,7-trisubstituted pyrazolo(4,3-d)pyrimidines or a pharmaceutically acceptable salt thereof in combination with cytostatics in the preparation of a medicament for treating cancer. (en)
Title	Novel pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy Novel pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy (en)
skos:prefLabel	Novel pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy Novel pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy (en)
skos:notation	RIV/61989592:15310/10:10212652!RIV11-GA0-15310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/08/1649), P(GA522/09/1576), Z(AV0Z5038910)
http://linked.open...cisloPatentuVzoru	CA2480409
http://linked.open...eleniPatentuVzoru	2010-06-22 (xsd:date)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Havlíček, Libor Kryštof, Vladimír Strnad, Miroslav Lenobel, René
http://linked.open.../riv/druhVysledku	P - Patent
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	275450
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/10:10212652
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	novel, pyrazolo[4,3-D]pyrimidines, process, preparation, method, therapy (en)
http://linked.open.../riv/klicoveSlovo	method therapy 3-D]pyrimidines process novel preparation pyrazolo[4
http://linked.open...ontrolniKodProRIV	[E4138C0AA5E8]
http://linked.open.../licencniPoplatek	A - Poskytovatel licence na výsledek požaduje licenční poplatek
http://linked.open...ydaniPatentuVzoru	Gatineau
http://linked.open...atelePatentuVzoru	Canadian Intellectual Property Office (CIPO) Industry Canada
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Modulation of cell division of normal and cancer cells by cyclin-dependent kinase inhibitors Development of biospecific ligands for affinity chromatography of cytokinin related proteins.
http://linked.open...UplatneniVysledku	2010
http://linked.open...ydaniPatentuVzoru	CA - Kanada
http://linked.open...iv/tvurceVysledku	Kryštof, Vladimír Strnad, Miroslav Lenobel, René HAVLÍČEK, Libor Moravcová, Daniela
http://linked.open...mniOchranaPatentu	D - Národní patentový úřad mimo ČR
http://linked.open...avai/riv/vlastnik	Univerzita Palackého v Olomouci a Ústav Experimentální Botaniky AV ČR v Praze
http://linked.open...itiJinymSubjektem	A - Nabytí licence je nutné vždy
http://linked.open...uzitiPatentuVzoru	B - Využívaný třetí stranou na základě licenční smlouvy
http://linked.open...n/vavai/riv/zamer	Physiological and genetical bases of plant development, cell cycle, morphogenesis, stress reactions and biotechnologies. Genome organisation and function
http://linked.open...stnikPatentuVzoru	Univerzita Palackého v Olomouci a Ústav Experimentální Botaniky AV ČR v Praze
http://localhost/t...ganizacniJednotka	15310

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