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rdf:type
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Description
| - Lovastatin showed anti-proliferative effects in vitro and led to significantly smaller tumor sizes in vivo compared to vehicle-treatment. 13cRA promoted tumor cell growth in vitro and led to significantly larger viable tumor mass and significantly faster increase of viable tumor mass in vivo over time compared to vehicle- and lovastatin-treatment. However, when combined with lovastatin, 13cRA enhanced the anti-proliferative effect of lovastatin in vivo. The combination-treated mice showed slowest tumor growth of all groups with significantly slower tumor growth compared to the vehicle-treated mice and significantly smaller tumor sizes. Moreover, the combination-treated group displayed the smallest size of viable tumor mass and the slowest increase in viable tumor mass over time of all groups, with a significant difference compared to the vehicle- and 13cRA-treated group. The combination-treated tumors showed highest extent of necrosis, lowest median microvessel density (MVD) and highest expression of alpha-smooth muscle actin. The combination of highe MVD and low alpha-SMA is a predictor of poor prognosis in other tumor entities.
- Lovastatin showed anti-proliferative effects in vitro and led to significantly smaller tumor sizes in vivo compared to vehicle-treatment. 13cRA promoted tumor cell growth in vitro and led to significantly larger viable tumor mass and significantly faster increase of viable tumor mass in vivo over time compared to vehicle- and lovastatin-treatment. However, when combined with lovastatin, 13cRA enhanced the anti-proliferative effect of lovastatin in vivo. The combination-treated mice showed slowest tumor growth of all groups with significantly slower tumor growth compared to the vehicle-treated mice and significantly smaller tumor sizes. Moreover, the combination-treated group displayed the smallest size of viable tumor mass and the slowest increase in viable tumor mass over time of all groups, with a significant difference compared to the vehicle- and 13cRA-treated group. The combination-treated tumors showed highest extent of necrosis, lowest median microvessel density (MVD) and highest expression of alpha-smooth muscle actin. The combination of highe MVD and low alpha-SMA is a predictor of poor prognosis in other tumor entities. (en)
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Title
| - Combination of 13-cis retinoid acid and lovastatin: marked anti-tumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice
- Combination of 13-cis retinoid acid and lovastatin: marked anti-tumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice (en)
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skos:prefLabel
| - Combination of 13-cis retinoid acid and lovastatin: marked anti-tumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice
- Combination of 13-cis retinoid acid and lovastatin: marked anti-tumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice (en)
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skos:notation
| - RIV/61989592:15110/14:33150458!RIV15-MSM-15110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/14:33150458
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - pheochromocytoma; 13-cis retinoic acid; lovastatin (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Schovánek, Jan
- Giubellino, Alessio
- Nolting, Svenja
- Tayem, Yasin
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issn
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number of pages
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http://bibframe.org/vocab/doi
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http://localhost/t...ganizacniJednotka
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