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Description
  • Unintended interactions of drugs present serious limitations to treatment success. Although a large number of membrane pumps have been identified as potential targets of cisplatin, vis-a-vis nephrotoxicity, NKA inhibition seems to be of crucial importance. Experiments with isolated large cytoplasmic segment C45 revealed that it is the main target of cisplatin on NKA and that the reaction with cysteine residues plays an important role in cisplatin/NKA interactions.
  • Unintended interactions of drugs present serious limitations to treatment success. Although a large number of membrane pumps have been identified as potential targets of cisplatin, vis-a-vis nephrotoxicity, NKA inhibition seems to be of crucial importance. Experiments with isolated large cytoplasmic segment C45 revealed that it is the main target of cisplatin on NKA and that the reaction with cysteine residues plays an important role in cisplatin/NKA interactions. (en)
Title
  • Na /K -ATPase inhibition by cisplatin and consequences for cisplatin nephrotoxicity
  • Na /K -ATPase inhibition by cisplatin and consequences for cisplatin nephrotoxicity (en)
skos:prefLabel
  • Na /K -ATPase inhibition by cisplatin and consequences for cisplatin nephrotoxicity
  • Na /K -ATPase inhibition by cisplatin and consequences for cisplatin nephrotoxicity (en)
skos:notation
  • RIV/61989592:15110/14:33150270!RIV15-MSM-15110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(LO1204), S
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 31316
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/14:33150270
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Nephrotoxicity; Glutathione; Cisplatin; Adverse effects (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [085F9654D08A]
http://linked.open...i/riv/nazevZdroje
  • Biomedical Papers-Olomouc
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 158
http://linked.open...iv/tvurceVysledku
  • Šebela, Marek
  • Vacek, Jan
  • Kubala, Martin
  • Zatloukalová, Martina
  • Huličiak, Miroslav
  • Geletičová, Jaroslava
http://linked.open...ain/vavai/riv/wos
  • 000338628200006
issn
  • 1213-8118
number of pages
http://bibframe.org/vocab/doi
  • 10.5507/bp.2014.018
http://localhost/t...ganizacniJednotka
  • 15110
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