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Description
| - Objective: To characterize the differences in various risk factors for atherosclerosis between individuals with apoB higher (H) and lower (L) than predicted from regression equation apoB vs LDL-C. Methods: We evaluated 391 dyslipidemic subjects not treated with hypolipidemic drugs. The measured parameters included lipid profile, apolipoproteins A-1 and B, markers of insulin resistance and inflammation/hemostasis. Results: Correlation coefficient between apoB and LDL-C was 0.9 (p<0.0001). Individuals with H apoB compared to L apoB had significantly higher sex and age adjusted BMI, waist circumference, insulin, HOMA (fasting insulinglucose/22,5), C-peptide, proinsulin, PAI-1, sICAM-1, sVCAM-1, t-PA, vWF, frequency of metabolic syndrome and lower values of TD, LDL-C and HDL-C (p<0,05 to <0.001 for all parameters). Conclusion: individuals with apoB higher than predicted by their LDL-C levels are more insulin resistant and have more atherogenic risk profile. Thus, at least for dyslipidemic patient
- Objective: To characterize the differences in various risk factors for atherosclerosis between individuals with apoB higher (H) and lower (L) than predicted from regression equation apoB vs LDL-C. Methods: We evaluated 391 dyslipidemic subjects not treated with hypolipidemic drugs. The measured parameters included lipid profile, apolipoproteins A-1 and B, markers of insulin resistance and inflammation/hemostasis. Results: Correlation coefficient between apoB and LDL-C was 0.9 (p<0.0001). Individuals with H apoB compared to L apoB had significantly higher sex and age adjusted BMI, waist circumference, insulin, HOMA (fasting insulinglucose/22,5), C-peptide, proinsulin, PAI-1, sICAM-1, sVCAM-1, t-PA, vWF, frequency of metabolic syndrome and lower values of TD, LDL-C and HDL-C (p<0,05 to <0.001 for all parameters). Conclusion: individuals with apoB higher than predicted by their LDL-C levels are more insulin resistant and have more atherogenic risk profile. Thus, at least for dyslipidemic patient (en)
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Title
| - Apolipoprotein B versus LDL-cholesterol: Association with other risk factors for atherosclerosis
- Apolipoprotein B versus LDL-cholesterol: Association with other risk factors for atherosclerosis (en)
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skos:prefLabel
| - Apolipoprotein B versus LDL-cholesterol: Association with other risk factors for atherosclerosis
- Apolipoprotein B versus LDL-cholesterol: Association with other risk factors for atherosclerosis (en)
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skos:notation
| - RIV/61989592:15110/09:00009786!RIV10-MZ0-15110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/09:00009786
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - apolipoprotein B; LDL-cholesterol; dyslipidemia; cardiometabolic risk; insulin resistance; metabolic syndrome; apolipoprotein B targets; guidelines (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Vaverková, Helena
- Halenka, Milan
- Karásek, David
- Novotný, Dalibor
- Lukeš, Jiří
- Frohlich, Jiří
- Jackuliaková, Dagmar
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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