About: Metabolism of sanguinarine: the facts and the myths

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Sanguinarin, kvartérní benzofenantridinový alkaloid, vykazuje antimikrobiální a protizánětlivou aktivitu a z tohoto důvodu je používán v přípravcích ústní hygieny a potravních doplňcích. Jeho metabolismus a osud v organismu je předmětem nepřetržitých vědeckých debat. V tomto článku sumarizujeme současné znalosti o metabolismu sanguinarinu. Ukazujeme zejména, že: (i) Sanguinarin není transformován na 3,4-benzakridin a že literatura popisující tuto sloučeninu jako metabolit sanguinarinu je založena na artefaktech a misinterpretacích, které se v průběhem času staly dogmatem; (ii) Sanguinarin je přeměňován na dihydrosanguinarin in vivo, a že tato konverze je pravděpodobně detoxikační dráhou; (iii) Biologická aktivity sanguinarinu je ovlivněna signální dráhou aryl uhlovodíkového receptoru. (cs) Sanguinarine, a quaternary benzo[c]phenanthridine alkaloid, exhibits antimicrobial and anti-inflammatory activities and for this reason it is used in dental hygiene products and feed additives. Its metabolism and disposition is the subject of constant scientific discourse. In this paper we summarize current knowledge on sanguinarine metabolism. We show in particular that: (i) Sanguinarine is not transformed to 3,4-benzacridine and that the literature reporting this compound as a metabolite of sanguinarine is based on artifacts and misinterpretations that in course of time have created a dogma; (ii) Sanguinarine is converted to dihydrosanguinarine in vivo, the conversion being tentatively a detoxication pathway; (iii) Aryl hydrocarbon receptor metabolic signaling pathways modulate sanguinarine biological activity. Sanguinarine, a quaternary benzo[c]phenanthridine alkaloid, exhibits antimicrobial and anti-inflammatory activities and for this reason it is used in dental hygiene products and feed additives. Its metabolism and disposition is the subject of constant scientific discourse. In this paper we summarize current knowledge on sanguinarine metabolism. We show in particular that: (i) Sanguinarine is not transformed to 3,4-benzacridine and that the literature reporting this compound as a metabolite of sanguinarine is based on artifacts and misinterpretations that in course of time have created a dogma; (ii) Sanguinarine is converted to dihydrosanguinarine in vivo, the conversion being tentatively a detoxication pathway; (iii) Aryl hydrocarbon receptor metabolic signaling pathways modulate sanguinarine biological activity. (en)
Title	Metabolism of sanguinarine: the facts and the myths Metabolismus sanguinarinu: Fakta a mýty (cs) Metabolism of sanguinarine: the facts and the myths (en)
skos:prefLabel	Metabolism of sanguinarine: the facts and the myths Metabolismus sanguinarinu: Fakta a mýty (cs) Metabolism of sanguinarine: the facts and the myths (en)
skos:notation	RIV/61989592:15110/07:00004398!RIV08-MSM-15110___
http://linked.open.../vavai/riv/strany	173-175
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Šimánek, Vilím Dvořák, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	433005
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/07:00004398
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Sanguinarine; Biotransformation; Metabolites; Cytochrome P450; Aryl hydrogen receptor (en)
http://linked.open.../riv/klicoveSlovo	Metabolites Cytochrome P450 Aryl hydrogen receptor Biotransformation Sanguinarine
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[9195F12B028F]
http://linked.open...i/riv/nazevZdroje	Current Drug Metabolism
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Dvořák, Zdeněk Šimánek, Vilím
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	1389-2002
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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