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rdf:type
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Description
| - Purine inhibitors of cyclin-dependent kinases attract attention as potential anticancer drugs because their first representative roscovitine recently entered clinical trials. Although well described in terms of structure-activity relationships, we still present here a novel modification of the purine scaffold influencing their inhibitory properties. The introduced C-8 substituents, however, lowered the CDK inhibitory activity of roscovitine, whereas the antiproliferative potential of several derivatives remained high.
- Purine inhibitors of cyclin-dependent kinases attract attention as potential anticancer drugs because their first representative roscovitine recently entered clinical trials. Although well described in terms of structure-activity relationships, we still present here a novel modification of the purine scaffold influencing their inhibitory properties. The introduced C-8 substituents, however, lowered the CDK inhibitory activity of roscovitine, whereas the antiproliferative potential of several derivatives remained high. (en)
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Title
| - 2,6,8,9-Tetrasubstituted Purines as New CDK1 Inhibitors.
- 2,6,8,9-Tetrasubstituted Purines as New CDK1 Inhibitors. (en)
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skos:prefLabel
| - 2,6,8,9-Tetrasubstituted Purines as New CDK1 Inhibitors.
- 2,6,8,9-Tetrasubstituted Purines as New CDK1 Inhibitors. (en)
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skos:notation
| - RIV/61389030:_____/03:56033101!RIV/2004/GA0/A56004/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA301/02/0475), P(KJB6137301), Z(AV0Z5020903), Z(AV0Z5038910), Z(MSM 153100007)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61389030:_____/03:56033101
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Purine inhibitors; cyclin-dependent kinases; roscovitine (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Bioorganic and Medicinal Chemistry Letters
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...ocetUcastnikuAkce
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http://linked.open...nichUcastnikuAkce
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Havlíček, Libor
- Hanuš, Jan
- Kuzma, Marek
- Kryštof, Vladimír
- Moravec, Jiří
- Strnad, Miroslav
- Lenobel, René
- Otyepka, M.
- Moravcová, Daniela
- Fuksová, K.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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