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rdf:type
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Description
| - Gamma-Fe2O3 nanoparticles obtained by coprecipitation of Fe(II) and Fe(III) chlorides with a base and subsequent oxidation were coated with a shell of hydrophilic biocompatible poly(N,N-dimethylacrylamide) (PDMAAm). Various initiators were attached to the iron oxide surface to enable the use of the “grafting-from“ approach for immobilization of PDMAAm. They included 2,2-azobis(2-methylpropanimidamide) dihydrochloride (AMPA), 2,2-azobis(N-hydroxy-2-methylpropanimidamide) dihydrochloride (ABHA) and 4-cyano-4-{[1-cyano-3-(N-hydroxycarbamoyl)-1-methylpropyl]azo}pentanoic acid (CCHPA). Engulfment of PDMAAm-coated γ-Fe2O3 nanoparticles by murine J774.2 macrophages was investigated. Only some nanoparticles were engulfed by the macrophages. PDMAAm-AMPA-γ-Fe2O3 and PDMAAm-ABHA-γ-Fe2O3 nanoparticles were rapidly engulfed by the cells. In contrast, neat γ-Fe2O3 and PDMAAm-CCHPA-γ-Fe2O3 particles induced formation of transparent vacuoles indicating toxicity of the particles. Thus, PDMAAm-coated AMPA- and ABHA-γ-Fe2O3 nanoparticles can be recommended as non-toxic labels for mammalian cells.
- Gamma-Fe2O3 nanoparticles obtained by coprecipitation of Fe(II) and Fe(III) chlorides with a base and subsequent oxidation were coated with a shell of hydrophilic biocompatible poly(N,N-dimethylacrylamide) (PDMAAm). Various initiators were attached to the iron oxide surface to enable the use of the “grafting-from“ approach for immobilization of PDMAAm. They included 2,2-azobis(2-methylpropanimidamide) dihydrochloride (AMPA), 2,2-azobis(N-hydroxy-2-methylpropanimidamide) dihydrochloride (ABHA) and 4-cyano-4-{[1-cyano-3-(N-hydroxycarbamoyl)-1-methylpropyl]azo}pentanoic acid (CCHPA). Engulfment of PDMAAm-coated γ-Fe2O3 nanoparticles by murine J774.2 macrophages was investigated. Only some nanoparticles were engulfed by the macrophages. PDMAAm-AMPA-γ-Fe2O3 and PDMAAm-ABHA-γ-Fe2O3 nanoparticles were rapidly engulfed by the cells. In contrast, neat γ-Fe2O3 and PDMAAm-CCHPA-γ-Fe2O3 particles induced formation of transparent vacuoles indicating toxicity of the particles. Thus, PDMAAm-coated AMPA- and ABHA-γ-Fe2O3 nanoparticles can be recommended as non-toxic labels for mammalian cells. (en)
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Title
| - The use of hydrophilic poly(N,N-dimethylacrylamide) for promoting engulfment of magnetic .gamma.-Fe2O3 nanoparticles by mammalian cells
- The use of hydrophilic poly(N,N-dimethylacrylamide) for promoting engulfment of magnetic .gamma.-Fe2O3 nanoparticles by mammalian cells (en)
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skos:prefLabel
| - The use of hydrophilic poly(N,N-dimethylacrylamide) for promoting engulfment of magnetic .gamma.-Fe2O3 nanoparticles by mammalian cells
- The use of hydrophilic poly(N,N-dimethylacrylamide) for promoting engulfment of magnetic .gamma.-Fe2O3 nanoparticles by mammalian cells (en)
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skos:notation
| - RIV/61389013:_____/13:00391930!RIV14-MSM-61389013
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(7E12053), P(GAP206/12/0381)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61389013:_____/13:00391930
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - maghemite; core-shell; nanoparticles (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Biomedical Nanotechnology
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Horák, Daniel
- Trchová, Miroslava
- Beneš, Milan J.
- Macková, Hana
- Hromádková, Jiřina
- Babič, Michal
- Boiko, N.
- Klyuchivska, O.
- Stoika, R.
- Zasońska, Beata Anna
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
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