About: Azido leaving group in enzymatic synthesis-small and efficient

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Enzymatic transglycosylation catalyzed by glycosidases is a respected method in carbohydrate synthesis. The spectrum of acceptors is practically infinite, contrary to glycosyl donors, which are usually nitrophenyl glycosides. Their major advantage is good reactivity, however, their low water solubility causes lower transglycosylation yields since high concentrations of substrates are needed to promote transglycosylation at the expense of donor hydrolysis. This is especially the case of modified glycoside donors where some OH groups are substituted with more lipophilic substituents. The solubility problems are generally incurred by hydrophobic leaving groups. Furthermore, commercial nitrophenyl glycosides are expensive and the yields of their syntheses may be unsatisfactory. Therefore, alternative glycosyl donors are emerging, such as 3-nitro- and 5-nitro-2-pyridyl glycosides, vinyl glycosides and glycosyl fluorides, which exhibit many properties common to glycosyl azides Enzymatic transglycosylation catalyzed by glycosidases is a respected method in carbohydrate synthesis. The spectrum of acceptors is practically infinite, contrary to glycosyl donors, which are usually nitrophenyl glycosides. Their major advantage is good reactivity, however, their low water solubility causes lower transglycosylation yields since high concentrations of substrates are needed to promote transglycosylation at the expense of donor hydrolysis. This is especially the case of modified glycoside donors where some OH groups are substituted with more lipophilic substituents. The solubility problems are generally incurred by hydrophobic leaving groups. Furthermore, commercial nitrophenyl glycosides are expensive and the yields of their syntheses may be unsatisfactory. Therefore, alternative glycosyl donors are emerging, such as 3-nitro- and 5-nitro-2-pyridyl glycosides, vinyl glycosides and glycosyl fluorides, which exhibit many properties common to glycosyl azides (en)
Title	Azido leaving group in enzymatic synthesis-small and efficient Azido leaving group in enzymatic synthesis-small and efficient (en)
skos:prefLabel	Azido leaving group in enzymatic synthesis-small and efficient Azido leaving group in enzymatic synthesis-small and efficient (en)
skos:notation	RIV/61388971:_____/10:00354023!RIV11-MSM-61388971
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(OC08049)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Bojarová, Pavla Křen, Vladimír
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	248320
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/10:00354023
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	carbohydrate synthesis; glycoside donors; glycosyl azides (en)
http://linked.open.../riv/klicoveSlovo	carbohydrate synthesis glycoside donors glycosyl azides
http://linked.open...ontrolniKodProRIV	[D6ACA7C1FD50]
http://linked.open...i/riv/mistoVydani	Thomas Graham House, Science Park, Milton Road
http://linked.open...i/riv/nazevZdroje	Carbohydrate Chemistry. Chemical and Biological Approaches
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...v/pocetStranKnihy	193 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Inhibitors of Angiogenesis: Design, Synthesis and Biological Exploitation
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Bojarová, Pavla Křen, Vladimír
number of pages	6 (xsd:int)
http://purl.org/ne...btex#hasPublisher	The Royal Society of Chemistry
https://schema.org/isbn	9781847550446

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