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rdf:type
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Description
| - Glycosyl azides are shown to be efficient donors for Alfa-galactosidases, Alfa-glucosidases and Alfa-mannosidases. Only Alfa-galactosidases do not cleave the respective glycosyl azide 1 and, moreover, they exhibit competitive inhibition (especially Alfa-galactosidase from Talaromyces flavus). High water solubility and ready synthesis of glycosyl azides enable transglycosylation reactions even with difficult acceptors like N-acetyl-D-mannosamine in good yields. The versatility of glycosyl azides was demonstrated in the synthesis of five disaccharides – two of them are described for the first time. All the reactions were highly regioselective, yielding isomers. Alfa-Galactosidase from E. coli proved to have the best synthetic capabilities. The present study shows that glycosyl azides are a valuable alternative to common p-nitrophenyl glycoside donors and in many synthetic reactions
- Glycosyl azides are shown to be efficient donors for Alfa-galactosidases, Alfa-glucosidases and Alfa-mannosidases. Only Alfa-galactosidases do not cleave the respective glycosyl azide 1 and, moreover, they exhibit competitive inhibition (especially Alfa-galactosidase from Talaromyces flavus). High water solubility and ready synthesis of glycosyl azides enable transglycosylation reactions even with difficult acceptors like N-acetyl-D-mannosamine in good yields. The versatility of glycosyl azides was demonstrated in the synthesis of five disaccharides – two of them are described for the first time. All the reactions were highly regioselective, yielding isomers. Alfa-Galactosidase from E. coli proved to have the best synthetic capabilities. The present study shows that glycosyl azides are a valuable alternative to common p-nitrophenyl glycoside donors and in many synthetic reactions (en)
- Práce ukazuje, že glykosylazidy jsou efektivní donory pro Alfa-galaktosidasy, Alfa-glukosidasy a Alfa-mannosidasy. Pouze Alfa-galaktosidasy neštěpí glykosylazid 1 a navíc vykazují kompetitivní inhibici (zvláště Alfa-galaktosidasa z Talaromyces flavus). Výborná rozpustnost ve vodě a jednoduchá syntéza glykosylazidů umožňují transglykosylační reakce s dobrými výtěžky i s problematickými akceptory jako N-acetyl-D-mannosamin. Všestrannost glykosylazidů byla demonstrována na syntéze pěti disacharidů, z nichž dva jsou popsány poprvé. Všechny reakce byly vysoce regioselektivní a vznikaly při nich isomery. Alfa-Galaktosidasa z E. coli měla nejlepší syntetické schopnosti. Tato studie ukazuje, že glykosylazidy jsou cennou alternativou běžně používaných p-nitrofenyl-glykosidových donorů v mnoha syntetických reakcích (cs)
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Title
| - Glycosyl Azides – An Alternative Way to Disaccharides
- Glycosyl Azides – An Alternative Way to Disaccharides (en)
- Glykosyl azidy – alternativní cesta k disacharidům (cs)
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skos:prefLabel
| - Glycosyl Azides – An Alternative Way to Disaccharides
- Glycosyl Azides – An Alternative Way to Disaccharides (en)
- Glykosyl azidy – alternativní cesta k disacharidům (cs)
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skos:notation
| - RIV/61388971:_____/07:00097666!RIV08-AV0-61388971
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA203/05/0172), P(IAA400200503), P(OC 136), P(OC 170), P(OC D25.001), V, Z(AV0Z50200510)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388971:_____/07:00097666
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - azides; enzyme calatysis; glycosylation (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Advanced Synthesis & Catalysis
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Bojarová, Pavla
- Křen, Vladimír
- Kuzma, Marek
- Monti, D.
- Pelantová, Helena
- Petrásková, Lucie
- Simerská, Pavla
- Ferrandi, E. E.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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