About: Immunization with a Circumsporozoite Epitope Fused to Bordetella pertussis Adenylate Cyclase in Conjunction with Cytotoxic T-Lymphocyte-Associated Antigen 4 Blockade Confers Protection against Plasmodium berghei Liver-Stage Malaria

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About: Immunization with a Circumsporozoite Epitope Fused to Bordetella pertussis Adenylate Cyclase in Conjunction with Cytotoxic T-Lymphocyte-Associated Antigen 4 Blockade Confers Protection against Plasmodium berghei Liver-Stage Malaria Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	V této práci jsme pro imunizaci myší použili ACT toxoid, který obsahoval epitop CSP Plasmodium berhei. To vedlo k indukci velkého počtu IFN-gamma-sekretujících CD8+ T buněk, ale nedošlo k vytvoření protektivní imunity. Avšak, pokud byla podána anti CTLA-4 protilátka během boost imunizace, bylo v myších dosaženo ochrany proti letální dávce sporozoitů P. berghei ANKA (ANtwerpKAtango) (cs) In the present study, we used for mice immunization recombinant detoxified ACT containing an epitope of Plasmodium berghei CSP. This induced a high number of IFN-gamma-secreting CD8+ T cells, while no protective immunity was achieved. In contrast, when anti-CTLA-4 was administered during boost immunization, complete protection against challenge with P. berghei ANKA (ANtwerpKAtango) sporozoites was induced in a number of mice In the present study, we used for mice immunization recombinant detoxified ACT containing an epitope of Plasmodium berghei CSP. This induced a high number of IFN-gamma-secreting CD8+ T cells, while no protective immunity was achieved. In contrast, when anti-CTLA-4 was administered during boost immunization, complete protection against challenge with P. berghei ANKA (ANtwerpKAtango) sporozoites was induced in a number of mice (en)
Title	Immunization with a Circumsporozoite Epitope Fused to Bordetella pertussis Adenylate Cyclase in Conjunction with Cytotoxic T-Lymphocyte-Associated Antigen 4 Blockade Confers Protection against Plasmodium berghei Liver-Stage Malaria Immunization with a Circumsporozoite Epitope Fused to Bordetella pertussis Adenylate Cyclase in Conjunction with Cytotoxic T-Lymphocyte-Associated Antigen 4 Blockade Confers Protection against Plasmodium berghei Liver-Stage Malaria (en) Imunizace adenylát cyklázovým toxinem Bordetella pertussis nesoucím epitop CSP spolu s blokací CTLA-4 receptoru zajištuje protekci proti malárii působené Plasmodium berghei (cs)
skos:prefLabel	Immunization with a Circumsporozoite Epitope Fused to Bordetella pertussis Adenylate Cyclase in Conjunction with Cytotoxic T-Lymphocyte-Associated Antigen 4 Blockade Confers Protection against Plasmodium berghei Liver-Stage Malaria Immunization with a Circumsporozoite Epitope Fused to Bordetella pertussis Adenylate Cyclase in Conjunction with Cytotoxic T-Lymphocyte-Associated Antigen 4 Blockade Confers Protection against Plasmodium berghei Liver-Stage Malaria (en) Imunizace adenylát cyklázovým toxinem Bordetella pertussis nesoucím epitop CSP spolu s blokací CTLA-4 receptoru zajištuje protekci proti malárii působené Plasmodium berghei (cs)
skos:notation	RIV/61388971:_____/06:00040375!RIV07-AV0-61388971
http://linked.open.../vavai/riv/strany	2277;2285
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IBS5020311), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Šimšová, Marcela Šebo, Peter Kamanová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	478865
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/06:00040375
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	plasmodium berghei; immunity; malaria (en)
http://linked.open.../riv/klicoveSlovo	malaria immunity plasmodium berghei
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[FEB7B12E1873]
http://linked.open...i/riv/nazevZdroje	Infection and Immunity
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Vaccines for induction of mucosal and systemic immunity
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	74
http://linked.open...iv/tvurceVysledku	Kamanová, Jana Šebo, Peter Fleischer, B. Heussler, V. Jacobs, T. Tartz, S. Šimšová, Marcela Bolte, S.
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0019-9567
number of pages	9 (xsd:int)

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