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rdf:type
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Description
| - %22Zapojení katecholaminových receptorů (alfa-adrenergní, D2-dopaminové) bylo studováno u stresovaných experimentálních zvířat. Stres vyvolal změněné imunitní odpovědi spojené se změnami signalizace G-proteiny, poškození TH1/TH2 cytokinové sítě a funkce buněk NK. Po aplikaci specifických antagonistů předcházející vyvolání stresu došlo k odstranění imunosuprese. D2–typ dopaminergní mechanismus representuje dominantní komponentu v regulaci Galfas/Galfai (1,2)Galfaq/11 -proteinu přenášejícího signál a fungujícího na obou -nervové a imunitní úrovni. S G-proteiny spojené receptory (GPCRs) mohou modulovat produkci cytokinů a hrát regulační úlohu v efektorových mechanismech imunity. (cs)
- The involvement of catecholamine receptors (alpha-adrenergic, D2-dopamine) was investigated in restraint animals. Stress influenced immune responses with concomitant changes of G-protein signal transduction. Impairment of TH1/TH2 cytokine network and natural killer (NK) cell function was observed. In vivo administration of specific antagonists prior to restraint stress reversed the immunosuppression. D2-type dopaminergic mechanism represents a dominant component in regulation of Galphas/Galphai(1,2)/Galphaq/11-protein signal transduction at level of both central nervous and immune systems. G-protein-coupled receptors (GPCRs) can modulate cytokine production and may play a regulatory role in immune effector mechanisms.
- The involvement of catecholamine receptors (alpha-adrenergic, D2-dopamine) was investigated in restraint animals. Stress influenced immune responses with concomitant changes of G-protein signal transduction. Impairment of TH1/TH2 cytokine network and natural killer (NK) cell function was observed. In vivo administration of specific antagonists prior to restraint stress reversed the immunosuppression. D2-type dopaminergic mechanism represents a dominant component in regulation of Galphas/Galphai(1,2)/Galphaq/11-protein signal transduction at level of both central nervous and immune systems. G-protein-coupled receptors (GPCRs) can modulate cytokine production and may play a regulatory role in immune effector mechanisms. (en)
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Title
| - Effects of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune reponsiveness of mice
- Effects of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune reponsiveness of mice (en)
- Účinek D2-dopaminových a alfa-adrenergních antagonistů na stresem indukované změny imunitní odpovedi u myší (cs)
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skos:prefLabel
| - Effects of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune reponsiveness of mice
- Effects of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune reponsiveness of mice (en)
- Účinek D2-dopaminových a alfa-adrenergních antagonistů na stresem indukované změny imunitní odpovedi u myší (cs)
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skos:notation
| - RIV/61388971:_____/02:00100411!RIV/2005/AV0/A53005/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA304/01/0850), P(GA310/98/0347), P(GV312/98/K034), Z(AV0Z5020903)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388971:_____/02:00100411
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - restraint stress; cytokine; nk cell (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Neuroimmunology
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Vannucci, Luca
- Kovářů, H.
- Fišerová, Anna
- Starec, M.
- Kuldová, M.
- Pospíšil, Miloslav
- Páv, M.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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