About: Synthesis of Substituted Benzyl Homo-C-Ribonucleosides and -Nucleotides as Carba-Analogues of Phosphoribosylanthranilate

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About: Synthesis of Substituted Benzyl Homo-C-Ribonucleosides and -Nucleotides as Carba-Analogues of Phosphoribosylanthranilate Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Title new 2-substituted benzyl-C-ribonucleosides and -nucleotides were designed as carba-analogues of phosphoribosylanthranilate, a key intermediate in tryptophan biosynthesis. The synthesis was based on preparation of TBS-protected 2-bromobenzyl-C-ribonucleoside by addition of 2-bromobenzylmagnesium bromide to ribonolactone followed by reduction and its follow-up functional group transformations. Some of the title nucleosides were converted to 5'-O-phosphates. Title new 2-substituted benzyl-C-ribonucleosides and -nucleotides were designed as carba-analogues of phosphoribosylanthranilate, a key intermediate in tryptophan biosynthesis. The synthesis was based on preparation of TBS-protected 2-bromobenzyl-C-ribonucleoside by addition of 2-bromobenzylmagnesium bromide to ribonolactone followed by reduction and its follow-up functional group transformations. Some of the title nucleosides were converted to 5'-O-phosphates. (en)
Title	Synthesis of Substituted Benzyl Homo-C-Ribonucleosides and -Nucleotides as Carba-Analogues of Phosphoribosylanthranilate Synthesis of Substituted Benzyl Homo-C-Ribonucleosides and -Nucleotides as Carba-Analogues of Phosphoribosylanthranilate (en)
skos:prefLabel	Synthesis of Substituted Benzyl Homo-C-Ribonucleosides and -Nucleotides as Carba-Analogues of Phosphoribosylanthranilate Synthesis of Substituted Benzyl Homo-C-Ribonucleosides and -Nucleotides as Carba-Analogues of Phosphoribosylanthranilate (en)
skos:notation	RIV/61388963:_____/12:00382182!RIV13-AV0-61388963
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP207/11/0344), P(IAA400550902)
http://linked.open...iv/cisloPeriodika	26
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Hocek, Michal Slavětínská, Lenka Kubelka, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	172991
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/12:00382182
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	C-nucleosides; homonucleosides; cross-coupling; nucleotides (en)
http://linked.open.../riv/klicoveSlovo	cross-coupling C-nucleosides nucleotides homonucleosides
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[B77394F0741B]
http://linked.open...i/riv/nazevZdroje	European Journal of Organic Chemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of modular syntheses of new C-nucleosides for studying DNA polymerase specificity and for the extension of the genetic alphabet Combinatorial and rational approaches for the synthesis and evaluation of novel modified nucleosides with cytostatic and antimicrobial activity
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Hocek, Michal Slavětínská, Lenka Kubelka, Tomáš
http://linked.open...ain/vavai/riv/wos	000308294700015
issn	1434-193X
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/ejoc.201200819

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