About: The G-Patch Domain of Mason-Pfizer Monkey Virus Is a Part of Reverse Transcriptase

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Mason Pfizer monkey virus (M-PMV), like some other betaretroviruses, encodes a glycine-rich domain, G-patch domain (GPD). Alanine scanning mutational analysis of its most highly conserved residues revealed that while the mutations or deletions of the GPD had no effect on M-PMV proteolytic polyprotein processing, assembly and RNA incorporation, they caused a reduction of reverse transcriptase (RT) activity resulting in a drop in M-PMV infectivity. Immunoprecipitation experiments suggested that the GPD is a part of RT and participate in its function. These data indicate that the M-PMV GPD functions as a part of reverse transcriptase rather than protease. Mason Pfizer monkey virus (M-PMV), like some other betaretroviruses, encodes a glycine-rich domain, G-patch domain (GPD). Alanine scanning mutational analysis of its most highly conserved residues revealed that while the mutations or deletions of the GPD had no effect on M-PMV proteolytic polyprotein processing, assembly and RNA incorporation, they caused a reduction of reverse transcriptase (RT) activity resulting in a drop in M-PMV infectivity. Immunoprecipitation experiments suggested that the GPD is a part of RT and participate in its function. These data indicate that the M-PMV GPD functions as a part of reverse transcriptase rather than protease. (en)
Title	The G-Patch Domain of Mason-Pfizer Monkey Virus Is a Part of Reverse Transcriptase The G-Patch Domain of Mason-Pfizer Monkey Virus Is a Part of Reverse Transcriptase (en)
skos:prefLabel	The G-Patch Domain of Mason-Pfizer Monkey Virus Is a Part of Reverse Transcriptase The G-Patch Domain of Mason-Pfizer Monkey Virus Is a Part of Reverse Transcriptase (en)
skos:notation	RIV/61388963:_____/12:00376625!RIV13-AV0-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), P(GA204/09/1388), P(ME 904), Z(AV0Z40550506), Z(MSM6046137305)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Pichová, Iva Štokrová, Jitka Rumlová, Michaela Günterová, Jana Křížová, Ivana Hadravová, Romana Doležal, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	138327
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/12:00376625
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA repair enzyme; retroviral protease; Toxoplasma gondii; leukemia-virus; containing RNA (en)
http://linked.open.../riv/klicoveSlovo	Toxoplasma gondii DNA repair enzyme containing RNA leukemia-virus retroviral protease
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B5E31B447177]
http://linked.open...i/riv/nazevZdroje	Journal of Virology
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20904 New Antivirals and Antineoplastics Characterization of novel host cell protein interacting with protease of Mason-Pfizer monkey virus
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	68
http://linked.open...iv/tvurceVysledku	Pichová, Iva Ruml, T. Štokrová, Jitka Rumlová, Michaela Günterová, Jana Křížová, Ivana Doležal, Michal Hadravová, Romana
http://linked.open...ain/vavai/riv/wos	000299862500009
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Teoretické základy potravinářských a biochemických technologií
issn	0022-538X
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1128/JVI.06638-11

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