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rdf:type
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Description
| - Structurally diverse, sugar-modified, thymine-containing nucleoside phosphonic acids were evaluated for their ability to inhibit thymidine phosphorylase purified from spontaneous T-cell lymphomas of an inbred Sprague-Dawley rat strain. From a large set of tested compounds, among them a number of pyrrolidine-based derivatives, 10 nucleotide analogues with IC50 values below 1 .mu.M were selected. Out of them, four compounds strongly inhibited the enzyme with IC50 values in a range of 11–45 nM. These most potent compounds might be bi-substrate analogues.
- Structurally diverse, sugar-modified, thymine-containing nucleoside phosphonic acids were evaluated for their ability to inhibit thymidine phosphorylase purified from spontaneous T-cell lymphomas of an inbred Sprague-Dawley rat strain. From a large set of tested compounds, among them a number of pyrrolidine-based derivatives, 10 nucleotide analogues with IC50 values below 1 .mu.M were selected. Out of them, four compounds strongly inhibited the enzyme with IC50 values in a range of 11–45 nM. These most potent compounds might be bi-substrate analogues. (en)
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Title
| - Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase
- Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase (en)
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skos:prefLabel
| - Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase
- Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase (en)
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skos:notation
| - RIV/61388963:_____/10:00345860!RIV11-GA0-61388963
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1QS400550501), P(2B06065), P(GA202/09/0193), P(GA203/09/0820), P(KAN200520801), P(LC06061), P(LC06077), P(NR9138), Z(AV0Z40550506)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
| - Votruba, Ivan
- Rinnová, Markéta
- Kočalka, Petr
- Rosenberg, Ivan
- Petrová, Magdalena
- Buděšínský, Miloš
- Pohl, Radek
- Rejman, Dominik
- Točík, Zdeněk
- Králíková, Šárka
- Páv, Ondřej
- Poláková, Ivana
- Liboska, Radek
- Vaněk, Václav
- Panova, Natalya
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388963:_____/10:00345860
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - phosphonate nucleotides; pyrrolidine; thymidine phosphorylase (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Bioorganic and Medicinal Chemistry Letters
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Buděšínský, Miloš
- Petrová, Magdalena
- Pohl, Radek
- Rosenberg, Ivan
- Votruba, Ivan
- Vaněk, Václav
- Rejman, Dominik
- Králíková, Šárka
- Panova, Natalya
- Páv, Ondřej
- Točík, Zdeněk
- Liboska, Radek
- Kočalka, Petr
- Rinnová, Markéta
- Tomečková, Ivana
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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