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rdf:type
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Description
| - A series of novel 7-deazapurine ribonucleosides bearing an alkyl, aryl or hetaryl group in position 6 and H, F, or Cl atom in position 7 has been prepared and showed to possess significant cytostatic effect in nanomolar concentrations. Intracellular phosphorylation to mono- and triphosphates, and the inhibition of total RNA synthesis was demonstrated in preliminary study of metabolism and mechanism of action studies.
- A series of novel 7-deazapurine ribonucleosides bearing an alkyl, aryl or hetaryl group in position 6 and H, F, or Cl atom in position 7 has been prepared and showed to possess significant cytostatic effect in nanomolar concentrations. Intracellular phosphorylation to mono- and triphosphates, and the inhibition of total RNA synthesis was demonstrated in preliminary study of metabolism and mechanism of action studies. (en)
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Title
| - 6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents
- 6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents (en)
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skos:prefLabel
| - 6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents
- 6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents (en)
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skos:notation
| - RIV/61388963:_____/10:00342338!RIV11-MSM-61388963
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1M0508), P(1QS400550501), S, Z(AV0Z40550506)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388963:_____/10:00342338
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - nucleosides; 7-deazapurines; cross-coupling; cytostatic activity (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Medicinal Chemistry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Cihlar, T.
- Hocek, Michal
- Mackman, R.
- Pohl, Radek
- Votruba, Ivan
- Birkuš, G.
- Džubák, P.
- Hajdúch, M.
- Nauš, Petr
- Ray, A. S.
- Wang, T.
- Ameral, R.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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