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rdf:type
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Description
| - Byl identifikován protein CR3-RP (protein podobný CR3 adhéznímu receptoru) u C. albicans. Blokování tohoto proteinu polyklonálními protilátkami snížilo schopnost C. albicans adherovat k bukálním epiteliálním buňkám a ovlivnilo tvorbu a tloušťku biofilmu, pozorovanou skenovacím konfokálním mikroskopem. Tyto výsledky ukazují, že CR3-RP by mohl sloužit pro vývoj vakcíny. (cs)
- The Candida antigen CR3-RP (complement receptor 3-related protein) was identified and characterized as a 'mimicry' protein, which might play a role in the adherence of Candida albicans. Blocking CR3-RP with polyclonal anti-CR3-RP serum reduced the ability of Candida to adhere to buccal epithelial cells and formation of biofilm by 28% (P,0.001), including changes in biofilm thickness and integrity detected by confocal laser scanning microscopy. These properties of CR3-RP suggest that it has potential for future vaccine development.
- The Candida antigen CR3-RP (complement receptor 3-related protein) was identified and characterized as a 'mimicry' protein, which might play a role in the adherence of Candida albicans. Blocking CR3-RP with polyclonal anti-CR3-RP serum reduced the ability of Candida to adhere to buccal epithelial cells and formation of biofilm by 28% (P,0.001), including changes in biofilm thickness and integrity detected by confocal laser scanning microscopy. These properties of CR3-RP suggest that it has potential for future vaccine development. (en)
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Title
| - Antibody response to the 45 kDa Candida albicans antigen in an animal model and potential role of the antigen in adherence
- Účinek protilatek proti 45 kDa proteinovému antigenu z Candidy albicans ve zvířecím modelu a jeho potenciální role v adherenci (cs)
- Antibody response to the 45 kDa Candida albicans antigen in an animal model and potential role of the antigen in adherence (en)
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skos:prefLabel
| - Antibody response to the 45 kDa Candida albicans antigen in an animal model and potential role of the antigen in adherence
- Účinek protilatek proti 45 kDa proteinovému antigenu z Candidy albicans ve zvířecím modelu a jeho potenciální role v adherenci (cs)
- Antibody response to the 45 kDa Candida albicans antigen in an animal model and potential role of the antigen in adherence (en)
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skos:notation
| - RIV/61388963:_____/08:00316278!RIV09-AV0-61388963
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(LC531), Z(AV0Z40550506)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388963:_____/08:00316278
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - candida albicans; CR3-RP antigen; adherence (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Medical Microbiology
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Pichová, Iva
- Chorvát, D.
- Borecká-Melkusová, S.
- Bujdáková, J.
- Gašperík, J.
- Jensen, D. B.
- Kolecká, A.
- Kucharíková, S.
- Lell, C.
- Paulovičová, E.
- Würzner, R.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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