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rdf:type
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Description
| - 8-Aza-7,9-dideazaxanthin byl připraven pomocí TosMIC a 1,3-dibenzyluracilu. Postup byl vylepšen užitím AlCl3 pro finální debenzylaci. 8-Alkyl-8-aza-7,9-dideazaxanthiny byly připraveny reakcí 6-dibromomethyl-5-formyluracilu s benzyl-, 4 methoxybenzyl-, a 1 adamantylaminem. Bylo zjištěno že N1- a N8-(8-fosfonooktyl)-8-aza-7,9-dideazaxanthin jsou učinnými inhibitory thymidin fosforylasy (V79 buňky, lidská placenta, Escherichia coli). Hodnoty IC50 3–27 .mu.M. (cs)
- The described preparation of 8-aza-7,9-dideazaxanthine from 1,3-dibenzyluracil and TosMIC was improved by using AlCl3 for final debenzylation. Treatment of 6-dibromomethyl- 5-formyluracil with benzyl-, 4-methoxybenzyl-, and 1-adamantylamine gave the corresponding 8-alkyl-8-aza-7,9-dideazaxanthines. N1- and N8-(8-phosphonooctyl)-8-aza-7,9-dideazaxanthines were prepared and found as inhibitors of thymidine phosphorylase (V79 cells, human placenta, Escherichia coli). IC50 values ranged at 3–27 .mu.M.
- The described preparation of 8-aza-7,9-dideazaxanthine from 1,3-dibenzyluracil and TosMIC was improved by using AlCl3 for final debenzylation. Treatment of 6-dibromomethyl- 5-formyluracil with benzyl-, 4-methoxybenzyl-, and 1-adamantylamine gave the corresponding 8-alkyl-8-aza-7,9-dideazaxanthines. N1- and N8-(8-phosphonooctyl)-8-aza-7,9-dideazaxanthines were prepared and found as inhibitors of thymidine phosphorylase (V79 cells, human placenta, Escherichia coli). IC50 values ranged at 3–27 .mu.M. (en)
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Title
| - Nucleosides and nucleotides containing 8-aza-7,9-dideazaxanthine
- Nukleosidy a nukleotidy obsahující 8-aza-7,9-dideazaxanthin (cs)
- Nucleosides and nucleotides containing 8-aza-7,9-dideazaxanthine (en)
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skos:prefLabel
| - Nucleosides and nucleotides containing 8-aza-7,9-dideazaxanthine
- Nukleosidy a nukleotidy obsahující 8-aza-7,9-dideazaxanthin (cs)
- Nucleosides and nucleotides containing 8-aza-7,9-dideazaxanthine (en)
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skos:notation
| - RIV/61388963:_____/08:00310039!RIV09-AV0-61388963
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1M0508), P(1QS400550501), Z(AV0Z40550506)
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388963:_____/08:00310039
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - 8-Aza-7,9-dideaza; xanthine; thymidine phosporylase; debenzylation (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...v/mistoKonaniAkce
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http://linked.open...i/riv/mistoVydani
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http://linked.open...i/riv/nazevZdroje
| - Chemistry of Nucleic Acid Components
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Dračínský, Martin
- Holý, Antonín
- Votruba, Ivan
- Otmar, Miroslav
- Mařák, David
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http://linked.open...vavai/riv/typAkce
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http://linked.open...ain/vavai/riv/wos
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http://linked.open.../riv/zahajeniAkce
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http://linked.open...n/vavai/riv/zamer
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number of pages
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http://purl.org/ne...btex#hasPublisher
| - Institute of Organic Chemistry and Biochemistry ASCR
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https://schema.org/isbn
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