About: Serum profiles of free and conjugated neuroactive pregnanolone isomers in nonpregnant women of fertile age     Goto   Sponge   Distinct   Permalink

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Description
  • Pregnanolone isomers (PI) are neuroinhibitors modulating GABAA receptors. In addition to the brain's in situ synthesis, some circulating steroids can penetrate the blood-brain barrier. To assess the physiological impact, PI and conjugates were measured in women in various phases of the menstrual cycle using GC/MS and RIA for the analysis. The levels of conjugated PI were higher than that of free steroids. Levels reflected changes in progesterone formation during the menstrual cycle.
  • Pregnanolone isomers (PI) are neuroinhibitors modulating GABAA receptors. In addition to the brain's in situ synthesis, some circulating steroids can penetrate the blood-brain barrier. To assess the physiological impact, PI and conjugates were measured in women in various phases of the menstrual cycle using GC/MS and RIA for the analysis. The levels of conjugated PI were higher than that of free steroids. Levels reflected changes in progesterone formation during the menstrual cycle. (en)
  • Pregnanolonové isomery (PI) jsou neuroinhibitory modulující GABAA receptory. Kromě syntézy in situ v mozku, některé cirkulující steroidy mohou prostoupit hematoencefalickou barierou. Ke zhodnocení fysiologického vlivu byly měřeny hladiny PI u žen v různých fázích menstruačního cyklu pomocí GC/MS a RIA analýzy. Hladiny konjugovaných PI jsou vyšší než hladiny volných steroidů. PI včetně konjugátů odrážejí změny v tvorbě progesteronu během menstruačního cyklu. (cs)
Title
  • Serum profiles of free and conjugated neuroactive pregnanolone isomers in nonpregnant women of fertile age
  • Serum profiles of free and conjugated neuroactive pregnanolone isomers in nonpregnant women of fertile age (en)
  • Sérové profily volných a konjugovaných neuroaktivních pregnanolonových isomerů u netěhotných žen v produktivním věku (cs)
skos:prefLabel
  • Serum profiles of free and conjugated neuroactive pregnanolone isomers in nonpregnant women of fertile age
  • Serum profiles of free and conjugated neuroactive pregnanolone isomers in nonpregnant women of fertile age (en)
  • Sérové profily volných a konjugovaných neuroaktivních pregnanolonových isomerů u netěhotných žen v produktivním věku (cs)
skos:notation
  • RIV/61388963:_____/06:00042101!RIV07-AV0-61388963
http://linked.open.../vavai/riv/strany
  • 3092;3099
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NR7768), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 8
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 499013
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/06:00042101
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • pregnanolone isomers; GABAA; steroids (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [215C482D46DE]
http://linked.open...i/riv/nazevZdroje
  • Journal of Clinical Endocrinology and Metabolism
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 91
http://linked.open...iv/tvurceVysledku
  • Pouzar, Vladimír
  • Černý, Ivan
  • Stárka, L.
  • Hill, M.
  • Kancheva, L.
  • Vrbíková, J.
  • Havlíková, H.
  • Kancheva, R.
http://linked.open...n/vavai/riv/zamer
issn
  • 0021-972X
number of pages
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