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Description
| - Syntéza tří monopyridiniových oximů a studium jejich schopnosti reaktivovat acetylcholinesterasu inhibovanou nervovými jedy (cs)
- There were synthesized three potential reactivators of nerve agents-inhibited acetylcholinesterase: 2-[(hydroxyimino)phenylmethyl]-1-methylpyridinium iodide 3a, 2-[(hydroxyimino)pyridin-2-ylmethyl]-1-methylpyridinium iodide 3b and 2-[(1-hydroxyimino) ethyl]-1-methylpyridinium iodide 3c. Their reactivation potency was examined using standard in vitro reactivation test. As the source of acetylcholinesterase was used rat brain homogenate. Their reactivation potency was compared with currently used acetylcholinesterase reactivator - 2-PAM (pralidoxime) 4. All tested reactivator were worse acetylcholinesterase reactivators in regard to 2-PAM. In this paper we have also tested reactivation potency of the oxime 2-PAM against inhibition acetylcholinesterase by sarin, cyclosarin, VX and tabun. Satisfactory results are shown only by reactivation sarin- and VX-inhibited acetylcholinesterase.
- There were synthesized three potential reactivators of nerve agents-inhibited acetylcholinesterase: 2-[(hydroxyimino)phenylmethyl]-1-methylpyridinium iodide 3a, 2-[(hydroxyimino)pyridin-2-ylmethyl]-1-methylpyridinium iodide 3b and 2-[(1-hydroxyimino) ethyl]-1-methylpyridinium iodide 3c. Their reactivation potency was examined using standard in vitro reactivation test. As the source of acetylcholinesterase was used rat brain homogenate. Their reactivation potency was compared with currently used acetylcholinesterase reactivator - 2-PAM (pralidoxime) 4. All tested reactivator were worse acetylcholinesterase reactivators in regard to 2-PAM. In this paper we have also tested reactivation potency of the oxime 2-PAM against inhibition acetylcholinesterase by sarin, cyclosarin, VX and tabun. Satisfactory results are shown only by reactivation sarin- and VX-inhibited acetylcholinesterase. (en)
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Title
| - Syntéza tří monopyridiniových oximů a studium jejich schopnosti reaktivovat acetylcholinesterasu inhibovanou nervovými jedy (cs)
- Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents
- Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents (en)
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skos:prefLabel
| - Syntéza tří monopyridiniových oximů a studium jejich schopnosti reaktivovat acetylcholinesterasu inhibovanou nervovými jedy (cs)
- Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents
- Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents (en)
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skos:notation
| - RIV/60461373:22310/04:00020154!RIV09-GA0-22310___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA203/01/1093), P(ONVLAJEP20031)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60461373:22310/04:00020154
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - VX; reactivation; acetylcholinesterase; oximes; sarin; tabun; cyclosarin (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Applied Biomedicine
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Cabal, Jiří
- Liška, František
- Pícha, Jan
- Kuča, Kamil.
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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