About: Histone deacetylase inhibition improves meiotic competence but not developmental competence in growing pig oocyte

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About: Histone deacetylase inhibition improves meiotic competence but not developmental competence in growing pig oocyte Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In fully-grown pig oocytes, meiotic maturation in vitro is retarded by inhibition ofhistone deacetylases by trichostatin A (TSA). In growing oocytes with partial meiotic competence, culture with TSA has no significant effect on the meitic maturation. Growing oocytes treated with TSA mature mainly to the stage of metaphase I. The ratio of oocytes maturing tothe stage of metaphase II is very limited. After transient exposure to TSA, the maturation of growing oocytes with partial meiotic competence takes a different course. When these oocytes are first cultured in a TSA-free medium, then cultured for another 24 hours with 100 nM TSA, and finally again inaTSA-free medium for 24 hours, the ratio of oocytes maturing to the stage of metaphase II significantly increases reaching 59%. When oocytes were cultured for the same length of time without transient exposure to TSA, only 19% matured to the stage of metaphase II. Those oocytes which matured to the stage of metaphase II after transient exposure toTSA In fully-grown pig oocytes, meiotic maturation in vitro is retarded by inhibition ofhistone deacetylases by trichostatin A (TSA). In growing oocytes with partial meiotic competence, culture with TSA has no significant effect on the meitic maturation. Growing oocytes treated with TSA mature mainly to the stage of metaphase I. The ratio of oocytes maturing tothe stage of metaphase II is very limited. After transient exposure to TSA, the maturation of growing oocytes with partial meiotic competence takes a different course. When these oocytes are first cultured in a TSA-free medium, then cultured for another 24 hours with 100 nM TSA, and finally again inaTSA-free medium for 24 hours, the ratio of oocytes maturing to the stage of metaphase II significantly increases reaching 59%. When oocytes were cultured for the same length of time without transient exposure to TSA, only 19% matured to the stage of metaphase II. Those oocytes which matured to the stage of metaphase II after transient exposure toTSA (en)
Title	Histone deacetylase inhibition improves meiotic competence but not developmental competence in growing pig oocyte Histone deacetylase inhibition improves meiotic competence but not developmental competence in growing pig oocyte (en)
skos:prefLabel	Histone deacetylase inhibition improves meiotic competence but not developmental competence in growing pig oocyte Histone deacetylase inhibition improves meiotic competence but not developmental competence in growing pig oocyte (en)
skos:notation	RIV/60460709:41210/09:31165!RIV10-MZE-41210___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(QG50052), Z(MSM6046070901)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kheilová, Kateřina Jílek, František Petr, Jaroslav Chmelíková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Česká zemědělská univerzita v Praze / Fakulta agrobiologie, potravinových a přírodních zdrojů
http://linked.open...dnocenehoVysledku	317213
http://linked.open...ai/riv/idVysledku	RIV/60460709:41210/09:31165
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	pig; oocyte; meiotic competence; activation; trichostatin A (en)
http://linked.open.../riv/klicoveSlovo	activation oocyte pig meiotic competence trichostatin A
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6543A037F373]
http://linked.open...i/riv/nazevZdroje	Zygote
http://linked.open...in/vavai/riv/obor	GG
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Reproductive biotechniques in pigs
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	17
http://linked.open...iv/tvurceVysledku	Jílek, František Petr, Jaroslav Chmelíková, Eva Kheilová, Kateřina
http://linked.open...n/vavai/riv/zamer	Setrvalé zemědělství, kvalita zemědělské produkce, krajinné a přírodní zdroje.
issn	0967-1994
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	41210

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