About: Influence of the distance between quaternary nitrogen and oxime group on the reactivation ability of oximes

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About: Influence of the distance between quaternary nitrogen and oxime group on the reactivation ability of oximes - antidotes against nerve agents Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.stmconnect.com/sites/default/files/41-43%20%20JEIT-D-12-00014.pdf
Description	Cholinesterase reactivators are a group of drugs originally developed as antidotes for treatment of nerve agent intoxications. Although there are five commercially available members of this group, none is considered to be a universal solution for treatment of intoxication caused by all nerve agents. Due to this, novel drug candidates are searched. To find the most promising antidotes, structure activity studies are conducted. In this contribution, distance between quaternary nitrogen and aldoxime (called oxime) group responsible for the reactivation process is discussed. For this purpose, three structurally different oxime reactivators were tested for their potency to reactivate tabun, sarin, cyclosarin and VX agent-inhibited acetylcholinesterase (AC hE; EC 3.1.1.7). As resulted, only %22standard%22 oxime reactivators with oxime group connected to the heteroaromatic ring could be considered as promising AC hE reactivators. Those with oxime group on other aromatic ring or those with quaternary nitrogen excluded from heteroarenium ring did not display any reactivation. Cholinesterase reactivators are a group of drugs originally developed as antidotes for treatment of nerve agent intoxications. Although there are five commercially available members of this group, none is considered to be a universal solution for treatment of intoxication caused by all nerve agents. Due to this, novel drug candidates are searched. To find the most promising antidotes, structure activity studies are conducted. In this contribution, distance between quaternary nitrogen and aldoxime (called oxime) group responsible for the reactivation process is discussed. For this purpose, three structurally different oxime reactivators were tested for their potency to reactivate tabun, sarin, cyclosarin and VX agent-inhibited acetylcholinesterase (AC hE; EC 3.1.1.7). As resulted, only %22standard%22 oxime reactivators with oxime group connected to the heteroaromatic ring could be considered as promising AC hE reactivators. Those with oxime group on other aromatic ring or those with quaternary nitrogen excluded from heteroarenium ring did not display any reactivation. (en)
Title	Influence of the distance between quaternary nitrogen and oxime group on the reactivation ability of oximes - antidotes against nerve agents Influence of the distance between quaternary nitrogen and oxime group on the reactivation ability of oximes - antidotes against nerve agents (en)
skos:prefLabel	Influence of the distance between quaternary nitrogen and oxime group on the reactivation ability of oximes - antidotes against nerve agents Influence of the distance between quaternary nitrogen and oxime group on the reactivation ability of oximes - antidotes against nerve agents (en)
skos:notation	RIV/60162694:G44__/13:43874790!RIV14-MZ0-G44_____
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NT12062)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Soukup, Ondřej Hrabinová, Martina Jun, Daniel Žďárová Karasová, Jana Kuča, Kamil Korábečný, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	79984
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/13:43874790
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acetylcholinesterase; antidote; nerve agent; reactivator; oxime (en)
http://linked.open.../riv/klicoveSlovo	acetylcholinesterase nerve agent oxime reactivator antidote
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[5B7733A9E207]
http://linked.open...i/riv/nazevZdroje	Journal of Environmental Immunology and Toxicology
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Preparation and biological evaluation of new therapeutics against to pesticides
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	1
http://linked.open...iv/tvurceVysledku	Hrabinová, Martina Kuča, Kamil Musílek, Kamil Žďárová Karasová, Jana Jun, Daniel Soukup, Ondřej Korábečný, Jan
issn	2225-1219
number of pages	3 (xsd:int)
http://bibframe.org/vocab/doi	10.7178/jeit.16
http://localhost/t...ganizacniJednotka	G44

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