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  • Organophosphorus compounds pose a potential threat to both military and civilian populations. Since post-exposure therapy has its limitations, our research was focused on the possibility of improving pretreatment in order to limit the toxic effects of tabun. We determined the protective index of various combinations of atropine, oximes (K074, K048, and TMB-4), and pyridostigmine given to mice before tabun intoxication. Although the tested oximes showed very good therapeutic efficacy in tabun-poisoned mice, the given pretreatments improved therapy against tabun poisoning. These regimens ensured survival of all animals up to 25.2 LD(50) of tabun. Our results indicate that even pretreatment with atropine alone is sufficiently effective in enhancing the survival of mice poisoned by multiple doses of tabun, if oxime therapy follows. K048 is our oxime of choice for future research, as it shows better protective and reactivating potency.
  • Organophosphorus compounds pose a potential threat to both military and civilian populations. Since post-exposure therapy has its limitations, our research was focused on the possibility of improving pretreatment in order to limit the toxic effects of tabun. We determined the protective index of various combinations of atropine, oximes (K074, K048, and TMB-4), and pyridostigmine given to mice before tabun intoxication. Although the tested oximes showed very good therapeutic efficacy in tabun-poisoned mice, the given pretreatments improved therapy against tabun poisoning. These regimens ensured survival of all animals up to 25.2 LD(50) of tabun. Our results indicate that even pretreatment with atropine alone is sufficiently effective in enhancing the survival of mice poisoned by multiple doses of tabun, if oxime therapy follows. K048 is our oxime of choice for future research, as it shows better protective and reactivating potency. (en)
Title
  • In vivo experimental approach to treatment against tabun poisoning
  • In vivo experimental approach to treatment against tabun poisoning (en)
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  • In vivo experimental approach to treatment against tabun poisoning
  • In vivo experimental approach to treatment against tabun poisoning (en)
skos:notation
  • RIV/60162694:G44__/10:00002420!RIV11-MO0-G44_____
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N
http://linked.open...iv/cisloPeriodika
  • 4
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http://linked.open...aciTvurceVysledku
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  • 263307
http://linked.open...ai/riv/idVysledku
  • RIV/60162694:G44__/10:00002420
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  • pretreatment; atropine; oxime; pyridostigmine; mice; tabun (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [23B253A794BB]
http://linked.open...i/riv/nazevZdroje
  • Journal of Enzyme Inhibition and Medicinal Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 25
http://linked.open...iv/tvurceVysledku
  • Kuča, Kamil
  • Berend, S.
  • Radic, B.
  • Vrdoljak, Ana Lucic
  • Katalinic, M.
  • Kovarik, Z.
http://linked.open...ain/vavai/riv/wos
  • 000280636800012
issn
  • 1475-6366
number of pages
http://localhost/t...ganizacniJednotka
  • G44
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