About: Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease     Goto   Sponge   Distinct   Permalink

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  • In this paper, series of 7-MEOTA analogues (N-alkyl-7-methoxytacrine) were synthesized. Their inhibitory ability was evaluated on recombinant human acetylcholinesterase (AChE) and plasmatic human butyrylcholinesterase (BChE). Three novel compounds showed promising results towards hAChE better to THA or 7-MEOTA. Three compounds resulted as potent inhibitors of hBChE. The SAR findings highlighted the C6-C7 N-alkyl chains for cholinesterase inhibition.
  • In this paper, series of 7-MEOTA analogues (N-alkyl-7-methoxytacrine) were synthesized. Their inhibitory ability was evaluated on recombinant human acetylcholinesterase (AChE) and plasmatic human butyrylcholinesterase (BChE). Three novel compounds showed promising results towards hAChE better to THA or 7-MEOTA. Three compounds resulted as potent inhibitors of hBChE. The SAR findings highlighted the C6-C7 N-alkyl chains for cholinesterase inhibition. (en)
Title
  • Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease
  • Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease (en)
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  • Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease
  • Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease (en)
skos:notation
  • RIV/60162694:G44__/10:00002299!RIV11-MO0-G44_____
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(OVUOFVZ200805), S
http://linked.open...iv/cisloPeriodika
  • 20
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 291482
http://linked.open...ai/riv/idVysledku
  • RIV/60162694:G44__/10:00002299
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • acetylcholinesterase; butyrylcholinesterase; Alzheimer disease; tacrine; 7-MEOTA; inhibition (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [8D32DCD8C62F]
http://linked.open...i/riv/nazevZdroje
  • Bioorganic & Medicinal Chemistry Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...v/svazekPeriodika
  • 20
http://linked.open...iv/tvurceVysledku
  • Dohnal, Vlastimil
  • Kuča, Kamil
  • Marek, Jan
  • Musílek, Kamil
  • Pohanka, Miroslav
  • Zemek, Filip
  • Korábečný, Jan
  • Opletalová, Veronika
  • Holas, Ondřej
  • Binder, Jiří
http://linked.open...ain/vavai/riv/wos
  • 000281963700030
issn
  • 0960-894X
number of pages
http://localhost/t...ganizacniJednotka
  • G44
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