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Description
| - Formerly, 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA) was investigated as promising tacrine analogue beneficial for its low toxicity compared to tacrine. In this study, novel 7-MEOTA derivatives were synthesized - namely - 9,9`-di-(alkane-1,omega-diyldiimino)-di-(7-methoxy-1,2,3,4-tetrahydroacridine) was prepared from the corresponding diiodoalkanes. The novel compounds exhibit anticholinesterase (acetylcholinesterase and butyrylcholinesterase) activity in vitro. The synthesis and in vitro data are summarized in this article.
- Formerly, 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA) was investigated as promising tacrine analogue beneficial for its low toxicity compared to tacrine. In this study, novel 7-MEOTA derivatives were synthesized - namely - 9,9`-di-(alkane-1,omega-diyldiimino)-di-(7-methoxy-1,2,3,4-tetrahydroacridine) was prepared from the corresponding diiodoalkanes. The novel compounds exhibit anticholinesterase (acetylcholinesterase and butyrylcholinesterase) activity in vitro. The synthesis and in vitro data are summarized in this article. (en)
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Title
| - Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA
- Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA (en)
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skos:prefLabel
| - Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA
- Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA (en)
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skos:notation
| - RIV/60162694:G44__/10:00002297!RIV11-MO0-G44_____
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(OVUOFVZ200805), S, Z(MSM0021620822)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/10:00002297
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - acetylcholinesterase; butyrylcholinesterase; Alzheimer`s disease; tacrine; inhibition selectivity (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - AE - Stát Spojené arabské emiráty
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Letters in Organic Chemistry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Dohnal, Vlastimil
- Kuča, Kamil
- Musílek, Kamil
- Pohanka, Miroslav
- Korábečný, Jan
- Opletalová, Veronika
- Holas, Ondřej
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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