About: Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA     Goto   Sponge   Distinct   Permalink

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  • Formerly, 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA) was investigated as promising tacrine analogue beneficial for its low toxicity compared to tacrine. In this study, novel 7-MEOTA derivatives were synthesized - namely - 9,9`-di-(alkane-1,omega-diyldiimino)-di-(7-methoxy-1,2,3,4-tetrahydroacridine) was prepared from the corresponding diiodoalkanes. The novel compounds exhibit anticholinesterase (acetylcholinesterase and butyrylcholinesterase) activity in vitro. The synthesis and in vitro data are summarized in this article.
  • Formerly, 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA) was investigated as promising tacrine analogue beneficial for its low toxicity compared to tacrine. In this study, novel 7-MEOTA derivatives were synthesized - namely - 9,9`-di-(alkane-1,omega-diyldiimino)-di-(7-methoxy-1,2,3,4-tetrahydroacridine) was prepared from the corresponding diiodoalkanes. The novel compounds exhibit anticholinesterase (acetylcholinesterase and butyrylcholinesterase) activity in vitro. The synthesis and in vitro data are summarized in this article. (en)
Title
  • Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA
  • Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA (en)
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  • Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA
  • Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA (en)
skos:notation
  • RIV/60162694:G44__/10:00002297!RIV11-MO0-G44_____
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(OVUOFVZ200805), S, Z(MSM0021620822)
http://linked.open...iv/cisloPeriodika
  • 4
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  • 291484
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  • RIV/60162694:G44__/10:00002297
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  • acetylcholinesterase; butyrylcholinesterase; Alzheimer`s disease; tacrine; inhibition selectivity (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • AE - Stát Spojené arabské emiráty
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  • [165C52A24E2F]
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  • Letters in Organic Chemistry
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  • 7
http://linked.open...iv/tvurceVysledku
  • Dohnal, Vlastimil
  • Kuča, Kamil
  • Musílek, Kamil
  • Pohanka, Miroslav
  • Korábečný, Jan
  • Opletalová, Veronika
  • Holas, Ondřej
http://linked.open...ain/vavai/riv/wos
  • 000277156500011
http://linked.open...n/vavai/riv/zamer
issn
  • 1570-1786
number of pages
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  • G44
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