Attributes | Values |
---|
rdf:type
| |
Description
| - The toxic effect of organophosphates is attributed to irreversible inhibition acetylcholinesterase (AChE; EC 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. Inhibition potency in vivo of one of the most toxic nerve agent - Russian VX (RVX; N,N-diethyl-2-[methyl-(2-methylpropoxy)phosphoryl]sulfanylethanamine) (1 x LD50 dose administered intramuscularly, i.m.) was studied in rats. AChE in blood was inhibited by 50%, 3 min after i.m. RVX. Butyrylcholinesterase (BChE; EC 3.1.1.8) in plasma was inhibited less rapidly and only 10-20%, 20 min after RVX. AChE and BChE activities in diaphragm were reduced only 30% and 15% at 30 min. While AChE and BChE activities were reduced only 20% and 15%, respectively, the decline in activity was rapid, occurring within 3 min. These findings indicate that RVX most potent inhibits ChE outsider the central nervous system.
- The toxic effect of organophosphates is attributed to irreversible inhibition acetylcholinesterase (AChE; EC 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. Inhibition potency in vivo of one of the most toxic nerve agent - Russian VX (RVX; N,N-diethyl-2-[methyl-(2-methylpropoxy)phosphoryl]sulfanylethanamine) (1 x LD50 dose administered intramuscularly, i.m.) was studied in rats. AChE in blood was inhibited by 50%, 3 min after i.m. RVX. Butyrylcholinesterase (BChE; EC 3.1.1.8) in plasma was inhibited less rapidly and only 10-20%, 20 min after RVX. AChE and BChE activities in diaphragm were reduced only 30% and 15% at 30 min. While AChE and BChE activities were reduced only 20% and 15%, respectively, the decline in activity was rapid, occurring within 3 min. These findings indicate that RVX most potent inhibits ChE outsider the central nervous system. (en)
|
Title
| - Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX
- Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX (en)
|
skos:prefLabel
| - Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX
- Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX (en)
|
skos:notation
| - RIV/60162694:G44__/09:00002130!RIV10-MO0-G44_____
|
http://linked.open...avai/riv/aktivita
| |
http://linked.open...avai/riv/aktivity
| |
http://linked.open...iv/cisloPeriodika
| |
http://linked.open...vai/riv/dodaniDat
| |
http://linked.open...aciTvurceVysledku
| |
http://linked.open.../riv/druhVysledku
| |
http://linked.open...iv/duvernostUdaju
| |
http://linked.open...titaPredkladatele
| |
http://linked.open...dnocenehoVysledku
| |
http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/09:00002130
|
http://linked.open...riv/jazykVysledku
| |
http://linked.open.../riv/klicovaSlova
| - Russian VX; acetylcholinesterase; butyrylcholinesterase; nerve agent (en)
|
http://linked.open.../riv/klicoveSlovo
| |
http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
http://linked.open...ontrolniKodProRIV
| |
http://linked.open...i/riv/nazevZdroje
| |
http://linked.open...in/vavai/riv/obor
| |
http://linked.open...ichTvurcuVysledku
| |
http://linked.open...cetTvurcuVysledku
| |
http://linked.open...UplatneniVysledku
| |
http://linked.open...v/svazekPeriodika
| |
http://linked.open...iv/tvurceVysledku
| - Bajgar, Jiří
- Kuča, Kamil
- Žďárová Karasová, Jana
- Jun, Daniel
- Pavlikova, Růžena
|
http://linked.open...ain/vavai/riv/wos
| |
http://linked.open...n/vavai/riv/zamer
| |
issn
| |
number of pages
| |
http://localhost/t...ganizacniJednotka
| |