About: The evaluation of neuroprotective efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats

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About: The evaluation of neuroprotective efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Oba nově vyvinuté oximy (K074, K075) stejně jako obidoxim jsou schopny redukovat cyklosarinem indukovanou akutní neurotoxicitu, ale jejich neuroprotektivní účinnost je signifikantně nižší ve srovnání s oximem HI-6. Proto je oxim HI-6 stále nejvhodnějším oximem pro antidotní terapii akutní otravy cyklosarinem vzhledem k jeho neuroprotektivní a reaktivační účinnosti. (cs) Both newly developed oximes (K074, K075) as well as obidoxime are also able to counteract cyclosarin-induced acute neurotoxicity but their neuroprotective potency is significantly lower compared to the oxime HI-6. Therefore, the oxime HI-6 is still the most suitable oxime for the antidotal treatment of acute poisonings with cyclosarin due to its neuroprotective as well as reactivating efficacy. Both newly developed oximes (K074, K075) as well as obidoxime are also able to counteract cyclosarin-induced acute neurotoxicity but their neuroprotective potency is significantly lower compared to the oxime HI-6. Therefore, the oxime HI-6 is still the most suitable oxime for the antidotal treatment of acute poisonings with cyclosarin due to its neuroprotective as well as reactivating efficacy. (en)
Title	Vyhodnocení neuroprotektivního účinku nově vyvinutých oximů (K074, K075) a v současnosti dostupných oximů (obidoxim, HI-6) na potkanech otrávených cyklosarinem (cs) The evaluation of neuroprotective efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats The evaluation of neuroprotective efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats (en)
skos:prefLabel	Vyhodnocení neuroprotektivního účinku nově vyvinutých oximů (K074, K075) a v současnosti dostupných oximů (obidoxim, HI-6) na potkanech otrávených cyklosarinem (cs) The evaluation of neuroprotective efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats The evaluation of neuroprotective efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats (en)
skos:notation	RIV/60162694:G44__/07:00001761!RIV08-MO0-G44_____
http://linked.open.../vavai/riv/strany	621-630
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Kassa, Jiří Žďárová Karasová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	420761
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/07:00001761
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cyclosarin; atropine; K oximes; HI-6; obidoxime; functional observational battery (en)
http://linked.open.../riv/klicoveSlovo	obidoxime cyclosarin HI-6 functional observational battery atropine K oximes
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[1118888C9347]
http://linked.open...i/riv/nazevZdroje	Journal of Applied Toxicology
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Kassa, Jiří Karasová, Jana Vašina, Libor
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	0260-437X
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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