About: Efficacy of structural homoloques and isomers of pralidoxime in reactivation of immobilised acetylcholinesterase inhibited with sarin, cyclosarin and soman

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About: Efficacy of structural homoloques and isomers of pralidoxime in reactivation of immobilised acetylcholinesterase inhibited with sarin, cyclosarin and soman Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Quantification of efficiency of monopyridinium isomers and homologs derived from clinical used pralidoxim within reactivation of acetylcholinesterase inhibited with organophosphorus nerve agents. This work uses the colorimetric biosensor called Detehit – cotton cloth with immobilized enzyme acetylcholinesterase. Biosensor is based on the modificated Ellman method. The highest reactivation was observed with sarin-inhibited acetylcholinesterase. Substantially lower reactivation was found with the cyclosarin-inhibited enzyme whereas AChE, inhibited by soman could not be effectively reactivated under the given conditions enzyme inhibition for 2 minutes and subsequent treatment with the reactivator for 15 minutes. Our work gives comparison of efficiency of reactivators in dependence on the lenght of alkylene chain and position of aldoxime functional group. Evaluation of effectivity of aldoxime reactivators is provided by simple means. Quantification of efficiency of monopyridinium isomers and homologs derived from clinical used pralidoxim within reactivation of acetylcholinesterase inhibited with organophosphorus nerve agents. This work uses the colorimetric biosensor called Detehit – cotton cloth with immobilized enzyme acetylcholinesterase. Biosensor is based on the modificated Ellman method. The highest reactivation was observed with sarin-inhibited acetylcholinesterase. Substantially lower reactivation was found with the cyclosarin-inhibited enzyme whereas AChE, inhibited by soman could not be effectively reactivated under the given conditions enzyme inhibition for 2 minutes and subsequent treatment with the reactivator for 15 minutes. Our work gives comparison of efficiency of reactivators in dependence on the lenght of alkylene chain and position of aldoxime functional group. Evaluation of effectivity of aldoxime reactivators is provided by simple means. (en)
Title	Efficacy of structural homoloques and isomers of pralidoxime in reactivation of immobilised acetylcholinesterase inhibited with sarin, cyclosarin and soman Efficacy of structural homoloques and isomers of pralidoxime in reactivation of immobilised acetylcholinesterase inhibited with sarin, cyclosarin and soman (en)
skos:prefLabel	Efficacy of structural homoloques and isomers of pralidoxime in reactivation of immobilised acetylcholinesterase inhibited with sarin, cyclosarin and soman Efficacy of structural homoloques and isomers of pralidoxime in reactivation of immobilised acetylcholinesterase inhibited with sarin, cyclosarin and soman (en)
skos:notation	RIV/60162694:G38__/09:#0000142!RIV10-MO0-G38_____
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MO0UOPZHN0401)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kobliha, Zbyněk Halámek, Emil Hoskovcová, Monika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany (nerozlišená součást)
http://linked.open...dnocenehoVysledku	312479
http://linked.open...ai/riv/idVysledku	RIV/60162694:G38__/09:#0000142
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acetylcholinesterase; acetylcholinesterase reactivators; chemical warfare agents; nerve agent; pralidoxime; sarin; cyclosarin; soman (en)
http://linked.open.../riv/klicoveSlovo	pralidoxime soman cyclosarin acetylcholinesterase chemical warfare agents sarin nerve agent acetylcholinesterase reactivators
http://linked.open...odStatuVydavatele	SE - Švédské království
http://linked.open...ontrolniKodProRIV	[F318FC0A5EA9]
http://linked.open...i/riv/nazevZdroje	Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor	KA
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	30
http://linked.open...iv/tvurceVysledku	Halámek, Emil Hoskovcová, Monika Kobliha, ZBYNĚK
http://linked.open...ain/vavai/riv/wos	000261553200013
http://linked.open...n/vavai/riv/zamer	Research of new methods and protection technologies against the effects of nuclear and chemical weapons
issn	0172-780X
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	G38

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