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rdf:type
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Description
| - Cyclohexyl methylphosphonofluoridate (cyclosarin, cyclosin, GF) is a highly toxic organophosphate, which was resistant to conventional oxime therapy. To give more insight into the reactivation kinetics, rat brain acetylcholinesterase (AChE) was inhibited in vitro by cyclosarin (pH 8.0, 25 °C) and reactivated with 22 different pyridinium-oximes. Only three compounds were shown to be superior to the other oximes: 4-carbamoyl-4´-[(hydroxyimino)methyl]-1,1´-(oxydimethylene)dipyridin-1-ium dichloride (HS-6), 4´-carbamoyl-2-[(hydroxyimino)methyl]-1,1´-(oxydimethylene)dipyridin-1-ium dichloride (HI-6), and 4´-carbamoyl-2-[(hydroxyimino)methyl]-1,1´-(but-2-ene-1,4-diyl)dipyridin-1-ium dichloride (BI-6).
- Cyclohexyl methylphosphonofluoridate (cyclosarin, cyclosin, GF) is a highly toxic organophosphate, which was resistant to conventional oxime therapy. To give more insight into the reactivation kinetics, rat brain acetylcholinesterase (AChE) was inhibited in vitro by cyclosarin (pH 8.0, 25 °C) and reactivated with 22 different pyridinium-oximes. Only three compounds were shown to be superior to the other oximes: 4-carbamoyl-4´-[(hydroxyimino)methyl]-1,1´-(oxydimethylene)dipyridin-1-ium dichloride (HS-6), 4´-carbamoyl-2-[(hydroxyimino)methyl]-1,1´-(oxydimethylene)dipyridin-1-ium dichloride (HI-6), and 4´-carbamoyl-2-[(hydroxyimino)methyl]-1,1´-(but-2-ene-1,4-diyl)dipyridin-1-ium dichloride (BI-6). (en)
- Reaktivace cyklosarinem inhibované acetylcholinesterázy pyridiniovými oximy (cs)
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Title
| - Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes
- Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes (en)
- Reaktivace cyklosarinem inhibované acetylcholinesterázy pyridiniovými oximy (cs)
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skos:prefLabel
| - Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes
- Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes (en)
- Reaktivace cyklosarinem inhibované acetylcholinesterázy pyridiniovými oximy (cs)
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skos:notation
| - RIV/60162694:G38__/04:00001080!RIV/2005/MO0/G38005/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G38__/04:00001080
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - acetylcholinesterase;oxime;reactivation;cyclosarin;in vitro (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Enzyme Inhibition and Medicinal Chemistry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Kuča, Kamil
- Patočka, Jiří
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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