About: Reactivation of organophosphate inhibited acetylcholinesterase activity by a,w-bis-(4-hydroxyiminomethylpyridinium) alcanes in vitro

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About: Reactivation of organophosphate inhibited acetylcholinesterase activity by a,w-bis-(4-hydroxyiminomethylpyridinium) alcanes in vitro Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this article, we have followed up the relationship between the ability to reactivate acetylcholinesterase inhibited by organophosphorus compounds and the length of linking chainbetween two 4-hydroxyiminomethylpyridinium rings of acetylcholinesterase reactivators. aw-bis(4-hydroxyiminomethylpyridinium) alkanes have been used as the tested acetylcholinesterase reactivators. These oximes differ in the number of methylene groups on the connecting chain. A three or four membered linking chain seems to bethe ideal length for the satisfactory reactivation potency with the exception of reactivators of cyclosarin-inhibited acetylcholinesterase. In this case, the most efficacious acetylcholinesterase reactivator has one methylene group on the connecting chain In this article, we have followed up the relationship between the ability to reactivate acetylcholinesterase inhibited by organophosphorus compounds and the length of linking chainbetween two 4-hydroxyiminomethylpyridinium rings of acetylcholinesterase reactivators. aw-bis(4-hydroxyiminomethylpyridinium) alkanes have been used as the tested acetylcholinesterase reactivators. These oximes differ in the number of methylene groups on the connecting chain. A three or four membered linking chain seems to bethe ideal length for the satisfactory reactivation potency with the exception of reactivators of cyclosarin-inhibited acetylcholinesterase. In this case, the most efficacious acetylcholinesterase reactivator has one methylene group on the connecting chain (en) Reaktivace aktivity acetylcholinesterázy inhibované organofosfáty pomocí a,w-bis-(4-hydroxyiminomethylpyridinium)alkanes in vitro (cs)
Title	Reaktivace aktivity acetylcholinesterázy inhibované organofosfáty pomocí a,w-bis-(4-hydroxyiminomethylpyridinium)alkanes in vitro (cs) Reactivation of organophosphate inhibited acetylcholinesterase activity by a,w-bis-(4-hydroxyiminomethylpyridinium) alcanes in vitro Reactivation of organophosphate inhibited acetylcholinesterase activity by a,w-bis-(4-hydroxyiminomethylpyridinium) alcanes in vitro (en)
skos:prefLabel	Reaktivace aktivity acetylcholinesterázy inhibované organofosfáty pomocí a,w-bis-(4-hydroxyiminomethylpyridinium)alkanes in vitro (cs) Reactivation of organophosphate inhibited acetylcholinesterase activity by a,w-bis-(4-hydroxyiminomethylpyridinium) alcanes in vitro Reactivation of organophosphate inhibited acetylcholinesterase activity by a,w-bis-(4-hydroxyiminomethylpyridinium) alcanes in vitro (en)
skos:notation	RIV/60162694:G38__/03:00000903!RIV/2005/MO0/G38005/N
http://linked.open.../vavai/riv/strany	207-211
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(OBVLAJEP20032), P(ON03021100001)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Cabal, Jiří Kuča, Kamil Patočka, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany (nerozlišená součást)
http://linked.open...dnocenehoVysledku	624635
http://linked.open...ai/riv/idVysledku	RIV/60162694:G38__/03:00000903
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acetylcholinesterase;organophosporus compounds;tabun;sarin;cyclosarin;VX (en)
http://linked.open.../riv/klicoveSlovo	cyclosarin VX acetylcholinesterase sarin tabun organophosporus compounds
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[46DDF41B2772]
http://linked.open...i/riv/nazevZdroje	Journal of Applied Biomedicine
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Possibilities of long impairment of immune functions after exposition to low sarin doses C-AGENTS - Medical problem of human being, animal andplant protection against topical types of military useable chemical agents
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	1
http://linked.open...iv/tvurceVysledku	Cabal, Jiří Kuča, Kamil Patočka, Jiří
issn	1214-021X
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	G38

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