About: Structural model of lymphocyte receptor NKR-P1C revealed bymass spectrometry and molecular modelling

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	NKR-P1C is an activating immune receptor expressed on the surface of mouse natural killer cells. It has been widely used as a marker for NK cell identification in different mice strains. Recently we solved a crystal structure of the C-type lectin-like domain of a homologous protein, NKR-P1A, using X-ray crystallography and also described the strategy for rapid characterization of the protein conformation in solution. This procedure utilized chemical cross-linking, hydrogen/deuterium exchange, and molecular modeling. It was found that the solution structure differs from the crystal structure in the conformation of the loop region. The loop, detached from the protein compact core in the crystal structure, is closely attached to the core of the protein in solution. Here we present and interpret the solution structure of the C-type lectin-like domain of NKR-P1C using chemical cross-linking and molecular modeling. The validation of the model and conformation of the loop region in NKR-P1C were addressed using ion-mobility mass spectrometry. NKR-P1C is an activating immune receptor expressed on the surface of mouse natural killer cells. It has been widely used as a marker for NK cell identification in different mice strains. Recently we solved a crystal structure of the C-type lectin-like domain of a homologous protein, NKR-P1A, using X-ray crystallography and also described the strategy for rapid characterization of the protein conformation in solution. This procedure utilized chemical cross-linking, hydrogen/deuterium exchange, and molecular modeling. It was found that the solution structure differs from the crystal structure in the conformation of the loop region. The loop, detached from the protein compact core in the crystal structure, is closely attached to the core of the protein in solution. Here we present and interpret the solution structure of the C-type lectin-like domain of NKR-P1C using chemical cross-linking and molecular modeling. The validation of the model and conformation of the loop region in NKR-P1C were addressed using ion-mobility mass spectrometry. (en)
Title	Structural model of lymphocyte receptor NKR-P1C revealed bymass spectrometry and molecular modelling Structural model of lymphocyte receptor NKR-P1C revealed bymass spectrometry and molecular modelling (en)
skos:prefLabel	Structural model of lymphocyte receptor NKR-P1C revealed bymass spectrometry and molecular modelling Structural model of lymphocyte receptor NKR-P1C revealed bymass spectrometry and molecular modelling (en)
skos:notation	RIV/60076658:12310/13:43883864!RIV14-MSM-12310___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM6007665808)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Ettrich, Rüdiger Sovová, Žofie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Jihočeská univerzita v Českých Budějovicích / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	108361
http://linked.open...ai/riv/idVysledku	RIV/60076658:12310/13:43883864
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	lymphocyte receptor, molecular modeling, solution structure, chemical cross-linking, hydrogen/deuterium exchange (en)
http://linked.open.../riv/klicoveSlovo	hydrogen/deuterium exchange lymphocyte receptor molecular modeling chemical cross-linking solution structure
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[8AF10A661332]
http://linked.open...i/riv/nazevZdroje	Analytical chemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	85
http://linked.open...iv/tvurceVysledku	Man, Petr Novák, Petr Rozbeský, Daniel Sovová, Žofie Ettrich, Ruediger Horst Marcoux, Julien Robinson, Carol V
http://linked.open...ain/vavai/riv/wos	000314676100051
http://linked.open...n/vavai/riv/zamer	Fyzikální biologie -nové přístupy v biologickém výzkumu
issn	0003-2700
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/ac302860m
http://localhost/t...ganizacniJednotka	12310

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