About: Cell therapy, a new standard in management of chronic critical limb ischemia and foot ulcer

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Fifty percent of diabetics (7% of general population) suffer from peripheral arterial occlusive disease, which may lead to amputation due to critical limb ischemia (CLI). The aim of our study was to prevent major limb amputation (MLA) in this group of patients using a local application of autologous bone marrow stem cells (ABMSC) concentrate. A total of 96 patients with CLI and foot ulcer (FU) were randomized into groups I and II. Patients in group I (n = 42, 36 males, 6 females, 66.2 +/- 10.6 years) underwent local treatment with ABMSC while those in group II (n = 54, control, 42 males, 12 females, 64.1 +/- 8.6 years) received standard medical care. The frequency of major limb amputation in groups I and II was 21% and 44% within the 120 days of follow up, respectively (p < 0.05). Only in salvaged limbs of group I both toe pressure and toe brachial index increased (from 22.66 +/- 5.32 to 25.63 +/- 4.75 mmHg and from 0.14 +/- 0.03 to 0.17 +/- 0.03, respectively, mean +/- SEM). The CD34( Fifty percent of diabetics (7% of general population) suffer from peripheral arterial occlusive disease, which may lead to amputation due to critical limb ischemia (CLI). The aim of our study was to prevent major limb amputation (MLA) in this group of patients using a local application of autologous bone marrow stem cells (ABMSC) concentrate. A total of 96 patients with CLI and foot ulcer (FU) were randomized into groups I and II. Patients in group I (n = 42, 36 males, 6 females, 66.2 +/- 10.6 years) underwent local treatment with ABMSC while those in group II (n = 54, control, 42 males, 12 females, 64.1 +/- 8.6 years) received standard medical care. The frequency of major limb amputation in groups I and II was 21% and 44% within the 120 days of follow up, respectively (p < 0.05). Only in salvaged limbs of group I both toe pressure and toe brachial index increased (from 22.66 +/- 5.32 to 25.63 +/- 4.75 mmHg and from 0.14 +/- 0.03 to 0.17 +/- 0.03, respectively, mean +/- SEM). The CD34( (en)
Title	Cell therapy, a new standard in management of chronic critical limb ischemia and foot ulcer Cell therapy, a new standard in management of chronic critical limb ischemia and foot ulcer (en)
skos:prefLabel	Cell therapy, a new standard in management of chronic critical limb ischemia and foot ulcer Cell therapy, a new standard in management of chronic critical limb ischemia and foot ulcer (en)
skos:notation	RIV/00843989:_____/10:00101513!RIV11-MZ0-00843989
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Urbanec, René Czerný, Daniel Jonszta, Tomáš Procházka, Václav Krajča, Jan Gumulec, Jaromír Jalůvka, František
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Ostrava
http://linked.open...dnocenehoVysledku	249830
http://linked.open...ai/riv/idVysledku	RIV/00843989:_____/10:00101513
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	critical limb ischemia (CLI); diabetic foot ulcer; autologous bone marrow stem cells (ABMSC); lymphopenia of bone marrow (en)
http://linked.open.../riv/klicoveSlovo	diabetic foot ulcer autologous bone marrow stem cells (ABMSC) critical limb ischemia (CLI) lymphopenia of bone marrow
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DFB972C27BD1]
http://linked.open...i/riv/nazevZdroje	Cell transplantation
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Gumulec, Jaromír Krajča, Jan Martínek, J. Procházka, Václav Jonszta, Tomáš Czerný, Daniel Klement, P. Jalůvka, František Šalounová, D. Urbanec, René Klement, G. L.
http://linked.open...ain/vavai/riv/wos	000286084900005
issn	0963-6897
number of pages	12 (xsd:int)

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