About: The MCP-1-2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population

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About: The MCP-1-2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Monocyte chemoattractant protein (MCP)-1 is the key chemokine in the process of atheroslerotic vascular inflammation. Examining already reported association between coronary artery disease (CAD) and the SNP A/G in the MCP-1 gene (position -2518), 139 Czech patients with CAD manifested as myocardial infarction (MI) and 359 unrelated healthy control (C) subjects were genotyped by PCR-SSP. Genotype and allele frequencies were not different in MI and C groups (allele G: MI, 20.5%; C, 23.8%, OR = 0.8, P > 0.05). No differences were detected when the patients were subdivided based on sex or the age of MI first occurrence. Further, no relationship was observed between circulating MCP-1 levels and carriage of the G allele. The data do not support a role for the MCP-1 -2518 single nucleotide polymorphism in susceptibility to CAD manifested by myocardial infarction Monocyte chemoattractant protein (MCP)-1 is the key chemokine in the process of atheroslerotic vascular inflammation. Examining already reported association between coronary artery disease (CAD) and the SNP A/G in the MCP-1 gene (position -2518), 139 Czech patients with CAD manifested as myocardial infarction (MI) and 359 unrelated healthy control (C) subjects were genotyped by PCR-SSP. Genotype and allele frequencies were not different in MI and C groups (allele G: MI, 20.5%; C, 23.8%, OR = 0.8, P > 0.05). No differences were detected when the patients were subdivided based on sex or the age of MI first occurrence. Further, no relationship was observed between circulating MCP-1 levels and carriage of the G allele. The data do not support a role for the MCP-1 -2518 single nucleotide polymorphism in susceptibility to CAD manifested by myocardial infarction (en) Protein MCP-1 je klíčovým chemokinem v procesu aterosklerotického zánětu. Studie ukazuje na vztah mezi kardiovaskulárním onemocněním a SNP A/G polymorfismem v genu (cs)
Title	The MCP-1-2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population V české populaci není polymorfismus MCP-1-2518 (A/G) asociován s infarktem myokardu (cs) The MCP-1-2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population (en)
skos:prefLabel	The MCP-1-2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population V české populaci není polymorfismus MCP-1-2518 (A/G) asociován s infarktem myokardu (cs) The MCP-1-2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population (en)
skos:notation	RIV/00843989:_____/05:00100007!RIV09-MZ0-00843989
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NI7308)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Čermáková, Zuzana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Ostrava
http://linked.open...dnocenehoVysledku	529147
http://linked.open...ai/riv/idVysledku	RIV/00843989:_____/05:00100007
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	coronary-artery-disease; chemoattractant protein-1; gene; genotype (en)
http://linked.open.../riv/klicoveSlovo	coronary-artery-disease gene genotype chemoattractant protein-1
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[986E10DD9D64]
http://linked.open...i/riv/nazevZdroje	International Journal of Immunogenetics
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Chemostatic cytokine MCP-1 and its receptors CCR2 and CCR5 in patients with atherosclerosis of coronary and peripheral arteries
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Čermáková, Zuzana
http://linked.open...ain/vavai/riv/wos	000231902900008
issn	1744-3121
number of pages	4 (xsd:int)

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