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Description
| - The reaction of methyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate with isocyanates and isothiocyanates has been used to prepare N-substituted methyl (3S)-2-aminocarbonyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylates. These compounds were cyclised by action of CF3COOH or triethylamine to give the corresponding 2-substituted (10aS)-10,10a-dihydroimidazo[1,5-b]isoquinoline-1,3(2H,5H)-diones (hydantoines Tic-H) and 2-substituted (10aS)-3-thioxo-1,2,3,5,10,10a-hexahydroimidazo[1,5-b]isoquinolin-1-ones (thiohydantoines Tic-TH) respectively. All the substances were characterised by means of 1H and 13C NMR spectra, elemental analyses, and the non-racemic substances also by means of optical rotation. The optical purity of selected substances was determined chromatographically.
- The reaction of methyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate with isocyanates and isothiocyanates has been used to prepare N-substituted methyl (3S)-2-aminocarbonyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylates. These compounds were cyclised by action of CF3COOH or triethylamine to give the corresponding 2-substituted (10aS)-10,10a-dihydroimidazo[1,5-b]isoquinoline-1,3(2H,5H)-diones (hydantoines Tic-H) and 2-substituted (10aS)-3-thioxo-1,2,3,5,10,10a-hexahydroimidazo[1,5-b]isoquinolin-1-ones (thiohydantoines Tic-TH) respectively. All the substances were characterised by means of 1H and 13C NMR spectra, elemental analyses, and the non-racemic substances also by means of optical rotation. The optical purity of selected substances was determined chromatographically. (en)
- Reakcí methyl (S)-1,2,3,4-tetrahydroisochinolin-3-carboxylátu s isokyanáty and isothiokyanáty byly připraveny N-substituované methyl (3S)-2-aminokarbonyl-1,2,3,4-tetrahydroisochinolin-3-karboxyláty. Tyto látky byly působením CF3COOH nebo triethylaminu cyklizovány na 2-substituované (10aS)-10,10a-dihydroimidazo[1,5-b]isochinolin-1,3(2H,5H)-diony (hydantoiny Tic-H) resp. 2-substituované (10aS)-3-thioxo-1,2,3,5,10,10a-hexahydroimidazo[1,5-b]isochinolin-1-ony (thiohydantoiny Tic-TH). Všechny látky byla charakterizovány 1H and 13C NMR spektry, elementárními analýzami, neracemické látky rovněž optickou rotací. Optická čistota vybraných látek byla stanovena chromatograficky. (cs)
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Title
| - Hydantoins and Thiohydantoins Derived from 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid
- Hydantoins and Thiohydantoins Derived from 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (en)
- Hydantoiny a thiohydantoiny odvozené od 1,2,3,4-tetrahydroisochinolin-3-karboxylové kyseliny (cs)
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skos:prefLabel
| - Hydantoins and Thiohydantoins Derived from 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid
- Hydantoins and Thiohydantoins Derived from 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (en)
- Hydantoiny a thiohydantoiny odvozené od 1,2,3,4-tetrahydroisochinolin-3-karboxylové kyseliny (cs)
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skos:notation
| - RIV/00216275:25310/06:00004386!RIV08-MSM-25310___
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216275:25310/06:00004386
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Tic Acid; Hydantoin; Thiohydantoin; Atropoisomer; NMR Spectrum; X-Ray; Chiral HPLC (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Jansa, Petr
- Wsól, Vladimír
- Macháček, Vladimír
- Bertolasi, Valerio
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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