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Description
| - Syntéza, strukturální studie, in vitro antitumorová a trypanocidalní aktivita tetrakis(3-methoxypropyl)stananu a 3-methoxypropylstanyl chloridů (cs)
- The set of four water-soluble (3-methoxypropyl)stannanes with the general formula (CH3OCH2CH2CH2)xSnCl4-x where x = 4 (1), x = 3 (2), x = 2 (3) and x = 1 (4), was prepared. For 3 and 4, which were isolated in crystalline state, it was shown by X ray diffraction that the tin atom is coordinated in distorted octahedral and trigonal-bipyramidal geometry, respectively, i.e. in both cases, the oxygen atoms of 3-methoxypropyl groups were coordinated to the central tin atom forming chelates. For all compounds, structures in CDCl3 and DMSO-d6 solutions were proposed from 13C and 119Sn NMR spectra. In CDCl3 solutions, the degree of donor-acceptor bonding between the central tin atom and oxygen atom of 3 methoxypropyl substituent was evaluated on the basis of 17O NMR chemical shifts and 3,6J(1H,119Sn) long-range coupling constants. Compounds 2 and 3 exhibited promising in vitro antitumour and trypanocidal activity.
- The set of four water-soluble (3-methoxypropyl)stannanes with the general formula (CH3OCH2CH2CH2)xSnCl4-x where x = 4 (1), x = 3 (2), x = 2 (3) and x = 1 (4), was prepared. For 3 and 4, which were isolated in crystalline state, it was shown by X ray diffraction that the tin atom is coordinated in distorted octahedral and trigonal-bipyramidal geometry, respectively, i.e. in both cases, the oxygen atoms of 3-methoxypropyl groups were coordinated to the central tin atom forming chelates. For all compounds, structures in CDCl3 and DMSO-d6 solutions were proposed from 13C and 119Sn NMR spectra. In CDCl3 solutions, the degree of donor-acceptor bonding between the central tin atom and oxygen atom of 3 methoxypropyl substituent was evaluated on the basis of 17O NMR chemical shifts and 3,6J(1H,119Sn) long-range coupling constants. Compounds 2 and 3 exhibited promising in vitro antitumour and trypanocidal activity. (en)
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Title
| - Syntéza, strukturální studie, in vitro antitumorová a trypanocidalní aktivita tetrakis(3-methoxypropyl)stananu a 3-methoxypropylstanyl chloridů (cs)
- Synthesis, Structural Study, In vitro Antitumour and Trypanocidal Activity of Tetrakis(3-methoxypropyl)tin and (3-Methoxypropyl)tin Chlorides
- Synthesis, Structural Study, In vitro Antitumour and Trypanocidal Activity of Tetrakis(3-methoxypropyl)tin and (3-Methoxypropyl)tin Chlorides (en)
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skos:prefLabel
| - Syntéza, strukturální studie, in vitro antitumorová a trypanocidalní aktivita tetrakis(3-methoxypropyl)stananu a 3-methoxypropylstanyl chloridů (cs)
- Synthesis, Structural Study, In vitro Antitumour and Trypanocidal Activity of Tetrakis(3-methoxypropyl)tin and (3-Methoxypropyl)tin Chlorides
- Synthesis, Structural Study, In vitro Antitumour and Trypanocidal Activity of Tetrakis(3-methoxypropyl)tin and (3-Methoxypropyl)tin Chlorides (en)
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skos:notation
| - RIV/00216275:25310/03:00000548!RIV08-MSM-25310___
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216275:25310/03:00000548
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Tin; Chelates; O ligands; Structure elucidation; Drug research (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - European Journal of Inorganic Chemistry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Bruhn, Clemens
- Brus, Jiří
- Lébl, Tomáš
- Smička, Aleš
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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