About: Epigenetic aspects of HP1 exchange kinetics in apoptotic chromatin

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Apoptotic bodies are the most condensed form of chromatin. In general, chromatin structure and function are mostly dictated by histone post-translational modifications.HP1 mobility in apoptotic cells appeared to be unique because limited exchange after photobleaching was observed for other epigenetically important proteins, including GFP-JMJD2b histone demethylase (similar to 10% fluorescence recovery) or Polycomb group-related GFP-BMI1 protein (similar to 20% fluorescence recovery). These findings imply a novel fact that only certain subset of proteins in apoptotic bodies is dynamic. Apoptotic bodies are the most condensed form of chromatin. In general, chromatin structure and function are mostly dictated by histone post-translational modifications.HP1 mobility in apoptotic cells appeared to be unique because limited exchange after photobleaching was observed for other epigenetically important proteins, including GFP-JMJD2b histone demethylase (similar to 10% fluorescence recovery) or Polycomb group-related GFP-BMI1 protein (similar to 20% fluorescence recovery). These findings imply a novel fact that only certain subset of proteins in apoptotic bodies is dynamic. (en)
Title	Epigenetic aspects of HP1 exchange kinetics in apoptotic chromatin Epigenetic aspects of HP1 exchange kinetics in apoptotic chromatin (en)
skos:prefLabel	Epigenetic aspects of HP1 exchange kinetics in apoptotic chromatin Epigenetic aspects of HP1 exchange kinetics in apoptotic chromatin (en)
skos:notation	RIV/00216224:14740/13:00066821!RIV14-MSM-14740___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(GAP302/10/1022), P(GBP302/12/G157), P(LD11020), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Zdráhal, Zbyněk Lochmanová, Gabriela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	73102
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/13:00066821
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Apoptosis; Histones; HP1; Epigenetics; Chromatin (en)
http://linked.open.../riv/klicoveSlovo	Histones Apoptosis Epigenetics HP1 Chromatin
http://linked.open...odStatuVydavatele	FR - Francouzská republika
http://linked.open...ontrolniKodProRIV	[67405AA12FBA]
http://linked.open...i/riv/nazevZdroje	Biochemistry & Molecular Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions Chromatin dynamics during DNA repair Epigenetics normal and tumor cells.
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	95
http://linked.open...iv/tvurceVysledku	Bártová, Eva Kozubek, Stanislav Zdráhal, Zbyněk Legartová, Soňa Stixová, Lenka Fojtová, Miloslava Lochmanová, Gabriela Jugová, Alžběta
http://linked.open...ain/vavai/riv/wos	000315614200006
http://linked.open...n/vavai/riv/zamer	Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0300-9084
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.biochi.2012.09.027
http://localhost/t...ganizacniJednotka	14740

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