About: Spatial Organization, Dynamics, and Associations of Telomeres in Healthy, Telomerase-Positive and ALT Human Cell Lines     Goto   Sponge   Distinct   Permalink

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  • The main goal of this study was to compare the telomere localizations, dynamics, and occurrences of telomere associations (TAs) in healthy cells, in tumor cells with active telomerase, and in tumor cells with mechanism of alternative lengthening of telomeres (ALT). These objectives were pursued by time-lapse microscopy of living cells and by visualizing telomeres with subtelomere DNA probes in repeated double-color fluorescence in situ hybridization (FISH) on 2D fixed nuclei. Samples were observed by high-resolution cytometry, and followed by image and statistical analysis of acquired data. As models for in situ experiments were chosen following lung tissue cell lines: cell line WI-38 (healthy lung fibroblasts), tumor cell line HT-1080 with active telomerase, and cell line WI-38 VA-13/2RA (VA-13) with ALT mechanism.
  • The main goal of this study was to compare the telomere localizations, dynamics, and occurrences of telomere associations (TAs) in healthy cells, in tumor cells with active telomerase, and in tumor cells with mechanism of alternative lengthening of telomeres (ALT). These objectives were pursued by time-lapse microscopy of living cells and by visualizing telomeres with subtelomere DNA probes in repeated double-color fluorescence in situ hybridization (FISH) on 2D fixed nuclei. Samples were observed by high-resolution cytometry, and followed by image and statistical analysis of acquired data. As models for in situ experiments were chosen following lung tissue cell lines: cell line WI-38 (healthy lung fibroblasts), tumor cell line HT-1080 with active telomerase, and cell line WI-38 VA-13/2RA (VA-13) with ALT mechanism. (en)
Title
  • Spatial Organization, Dynamics, and Associations of Telomeres in Healthy, Telomerase-Positive and ALT Human Cell Lines
  • Spatial Organization, Dynamics, and Associations of Telomeres in Healthy, Telomerase-Positive and ALT Human Cell Lines (en)
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  • Spatial Organization, Dynamics, and Associations of Telomeres in Healthy, Telomerase-Positive and ALT Human Cell Lines
  • Spatial Organization, Dynamics, and Associations of Telomeres in Healthy, Telomerase-Positive and ALT Human Cell Lines (en)
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  • RIV/00216224:14330/07:00020821!RIV11-GA0-14330___
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  • P(GP204/05/P090), P(LC535), Z(MSM0021622419)
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  • 451414
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  • RIV/00216224:14330/07:00020821
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  • telomere; chromosome; spatial organization; telomerase; ALT mechanism (en)
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  • [2F7F607B0B37]
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  • Kozubek, Stanislav
  • Lukášová, Emilie
  • Medříková, Daša
  • Kozubek, Michal
  • Vařecha, Miroslav
  • Fajkus, Jiří
  • Amrichová, Jana
http://linked.open...n/vavai/riv/zamer
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  • 14330
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