About: Spatial Organization, Dynamics, and Associations of Telomeres in Healthy, Telomerase-Positive and ALT Human Cell Lines

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The main goal of this study was to compare the telomere localizations, dynamics, and occurrences of telomere associations (TAs) in healthy cells, in tumor cells with active telomerase, and in tumor cells with mechanism of alternative lengthening of telomeres (ALT). These objectives were pursued by time-lapse microscopy of living cells and by visualizing telomeres with subtelomere DNA probes in repeated double-color fluorescence in situ hybridization (FISH) on 2D fixed nuclei. Samples were observed by high-resolution cytometry, and followed by image and statistical analysis of acquired data. As models for in situ experiments were chosen following lung tissue cell lines: cell line WI-38 (healthy lung fibroblasts), tumor cell line HT-1080 with active telomerase, and cell line WI-38 VA-13/2RA (VA-13) with ALT mechanism. The main goal of this study was to compare the telomere localizations, dynamics, and occurrences of telomere associations (TAs) in healthy cells, in tumor cells with active telomerase, and in tumor cells with mechanism of alternative lengthening of telomeres (ALT). These objectives were pursued by time-lapse microscopy of living cells and by visualizing telomeres with subtelomere DNA probes in repeated double-color fluorescence in situ hybridization (FISH) on 2D fixed nuclei. Samples were observed by high-resolution cytometry, and followed by image and statistical analysis of acquired data. As models for in situ experiments were chosen following lung tissue cell lines: cell line WI-38 (healthy lung fibroblasts), tumor cell line HT-1080 with active telomerase, and cell line WI-38 VA-13/2RA (VA-13) with ALT mechanism. (en)
Title	Spatial Organization, Dynamics, and Associations of Telomeres in Healthy, Telomerase-Positive and ALT Human Cell Lines Spatial Organization, Dynamics, and Associations of Telomeres in Healthy, Telomerase-Positive and ALT Human Cell Lines (en)
skos:prefLabel	Spatial Organization, Dynamics, and Associations of Telomeres in Healthy, Telomerase-Positive and ALT Human Cell Lines Spatial Organization, Dynamics, and Associations of Telomeres in Healthy, Telomerase-Positive and ALT Human Cell Lines (en)
skos:notation	RIV/00216224:14330/07:00020821!RIV11-GA0-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP204/05/P090), P(LC535), Z(MSM0021622419)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Amrichová, Jana Vařecha, Miroslav Kozubek, Michal Kozubek, Stanislav Fajkus, Jiří Lukášová, Emilie Medříková, Daša
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	451414
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/07:00020821
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	telomere; chromosome; spatial organization; telomerase; ALT mechanism (en)
http://linked.open.../riv/klicoveSlovo	telomerase chromosome spatial organization telomere ALT mechanism
http://linked.open...ontrolniKodProRIV	[2F7F607B0B37]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Chromosome dynamics and organization during the cell cycle in normal and pathologic conditions Topographic and functional characterization of telomeres in various tumor cell lines determined in situ and in vivo
http://linked.open...UplatneniVysledku	2007
http://linked.open...iv/tvurceVysledku	Kozubek, Stanislav Lukášová, Emilie Medříková, Daša Kozubek, Michal Vařecha, Miroslav Fajkus, Jiří Amrichová, Jana
http://linked.open...n/vavai/riv/zamer	Highly Parallel and Distributed Computing Systems
http://localhost/t...ganizacniJednotka	14330

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