About: Technique of light chain-specific immunofluorescent staining of clonal plasma cells and FISH analysis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	MULTIPLE MYELOMA (MM) is characterized by monoclonal proliferation of plasma cells and represents approximately 10% of all hematologic malignancies. The clinical course of patients with MM is highly variable. Reliable genetic indicators are therefore required for their stratification and for more adequate therapy. The metaphase cytogenetic studies in MM are hampered by a low proliferative activity of myeloma cells in vitro. Therefore, interphase fluorescent in situ hybridization (I-FISH) using specific DNA probes is the technique of choice for the determination of genomic aberrations associated with this disease. However, I-FISH on bone marrow specimens do not distinguish malignant plasma cells. In order to solve this problem, various novel techniques have been designated for selection of myeloma cells. Immunofluorescent labelling of malignant plasma cells is suitable approach for the diagnosis of chromosomal abnormalities in patients with MM. MULTIPLE MYELOMA (MM) is characterized by monoclonal proliferation of plasma cells and represents approximately 10% of all hematologic malignancies. The clinical course of patients with MM is highly variable. Reliable genetic indicators are therefore required for their stratification and for more adequate therapy. The metaphase cytogenetic studies in MM are hampered by a low proliferative activity of myeloma cells in vitro. Therefore, interphase fluorescent in situ hybridization (I-FISH) using specific DNA probes is the technique of choice for the determination of genomic aberrations associated with this disease. However, I-FISH on bone marrow specimens do not distinguish malignant plasma cells. In order to solve this problem, various novel techniques have been designated for selection of myeloma cells. Immunofluorescent labelling of malignant plasma cells is suitable approach for the diagnosis of chromosomal abnormalities in patients with MM. (en)
Title	Technique of light chain-specific immunofluorescent staining of clonal plasma cells and FISH analysis Technique of light chain-specific immunofluorescent staining of clonal plasma cells and FISH analysis (en)
skos:prefLabel	Technique of light chain-specific immunofluorescent staining of clonal plasma cells and FISH analysis Technique of light chain-specific immunofluorescent staining of clonal plasma cells and FISH analysis (en)
skos:notation	RIV/00216224:14330/06:00018067!RIV10-MZ0-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR8183), Z(MSM0021622415)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kuglík, Petr Hájek, Roman Filková, Hana Oltová, Alexandra Smejkalová, Jana
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	503126
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/06:00018067
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Multiple myeloma; FISH; chromosomal aberrations (en)
http://linked.open.../riv/klicoveSlovo	FISH chromosomal aberrations Multiple myeloma
http://linked.open...ontrolniKodProRIV	[1F7236901BA7]
http://linked.open...v/mistoKonaniAkce	Brno, ILBIT MU, Kamenice 5
http://linked.open...i/riv/mistoVydani	Brno
http://linked.open...i/riv/nazevZdroje	Detection of chromosomal aberrations in multiple myeloma
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular-cytogenetic analysis of marked plasma cells and prognostic significance of clonal chromosomal aberrations in multiple myeloma
http://linked.open...UplatneniVysledku	2006
http://linked.open...iv/tvurceVysledku	Hájek, Roman Kuglík, Petr Filková, Hana Oltová, Alexandra Smejkalová, Jana
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2006-10-25 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Masaryk University
https://schema.org/isbn	80-210-4129-3
http://localhost/t...ganizacniJednotka	14330

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