About: Topographic characterization of telomeres in healthy and various tumor cell lines determined in situ and in vivo

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About: Topographic characterization of telomeres in healthy and various tumor cell lines determined in situ and in vivo Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nuclear and territorial positioning of p- and q- telomeres and centromeres of chromosomes 3, 8, 9, 13 and 19 were studied using repeated fluorescence in situ hybridization, high-resolution image cytometry and three-dimensional image analysis of human blood lymphocytes before and after stimulation (Amrichová et al., 2003). Our results suggest that in both G0- and stimulated lymphocytes, centromeres of HSA 3, 8, 9, and 13 are predominantly localized at the periphery of the cell nucleus; only centromere of HSA 19 in G0-lymphocytes is localized more centrally. Both p- and q-telomeres mostly adopt positions in the nuclear interior; q-telomeres are usually nearer to the center of the cell nucleus as compared to p-telomeres. Using repeated hybridization, tethering between telomeres of heterologous chromosomes 8, 9, and 19 was investigated. An attempt was made to find which particular telomeres are involved in telomere associations and whether any associations can be found also between homologous telomeres. W Nuclear and territorial positioning of p- and q- telomeres and centromeres of chromosomes 3, 8, 9, 13 and 19 were studied using repeated fluorescence in situ hybridization, high-resolution image cytometry and three-dimensional image analysis of human blood lymphocytes before and after stimulation (Amrichová et al., 2003). Our results suggest that in both G0- and stimulated lymphocytes, centromeres of HSA 3, 8, 9, and 13 are predominantly localized at the periphery of the cell nucleus; only centromere of HSA 19 in G0-lymphocytes is localized more centrally. Both p- and q-telomeres mostly adopt positions in the nuclear interior; q-telomeres are usually nearer to the center of the cell nucleus as compared to p-telomeres. Using repeated hybridization, tethering between telomeres of heterologous chromosomes 8, 9, and 19 was investigated. An attempt was made to find which particular telomeres are involved in telomere associations and whether any associations can be found also between homologous telomeres. W (en) Topografická in situ a in vivo charakterizace telomeru stanovená ve zdravých a v různých typech nádorových buněčných liniích. (cs)
Title	Topografická in situ a in vivo charakterizace telomeru stanovená ve zdravých a v různých typech nádorových buněčných liniích (cs) Topographic characterization of telomeres in healthy and various tumor cell lines determined in situ and in vivo Topographic characterization of telomeres in healthy and various tumor cell lines determined in situ and in vivo (en)
skos:prefLabel	Topografická in situ a in vivo charakterizace telomeru stanovená ve zdravých a v různých typech nádorových buněčných liniích (cs) Topographic characterization of telomeres in healthy and various tumor cell lines determined in situ and in vivo Topographic characterization of telomeres in healthy and various tumor cell lines determined in situ and in vivo (en)
skos:notation	RIV/00216224:14330/04:00009715!RIV09-MZ0-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA202/02/0804), P(GA301/01/0186), P(IAA5004306), P(IBS5004010), P(ME 565), P(NC6987), Z(MSM 143300002)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Amrichová, Jana Vařecha, Miroslav Kozubek, Michal Kozubek, Stanislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	590469
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/04:00009715
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Telomere (en)
http://linked.open.../riv/klicoveSlovo	Telomere
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[799E507F7AB2]
http://linked.open...i/riv/nazevZdroje	Cytometry
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20565 Investigation of the local control of gene expression using spectral microscopy and omage analysis techniques Epigenetic control of gene expression in malignant diseases Chronic myeloid leukemia radiation risk estimation based on BCR-ABL distances in hemotopoietic cells Human genome structure Development of new diagnostic techniques for oncology
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	59A
http://linked.open...iv/tvurceVysledku	Kozubek, Stanislav Lukášová, Emilie Ondřej, Vladan Kozubek, Michal Vařecha, Miroslav Amrichová, Jana
http://linked.open...ain/vavai/riv/wos	000221319900197
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20143300002
issn	0196-4763
number of pages	1 (xsd:int)
http://localhost/t...ganizacniJednotka	14330

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