About: Cytological study of DNA methylation and histone methylation patterns in human cell lines

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Epigenetic processes are defined as heritable changes in genome function that occur without a change in DNA sequence. Gene expression, chromosome segregation, DNA replication, repair, and recombination all act, not on DNA alone, but on the chromatin template. DNA methylation, along with histone lysine methylation, establishes the framework for long-term epigenetic maintenance. The discovery that enzymes can (re)organise chromatin into accessible and inaccessible configurations revealed epigenetic mechanisms that considerably extend the information potential of the genetic code. In mammals, heterochromatin is characterised by DNA methylation at CpG dinucleotides and methylation at lysine 9 of histone 3 (H3- K9), whereas euchromatin is associated with methylation at lysine 4 of histone 3 (H3-K4). In our experiments, the detection of DNA methylated regions at chromosomal level was performed using indirect immunofluorescence technique combined with FISH. Epigenetic processes are defined as heritable changes in genome function that occur without a change in DNA sequence. Gene expression, chromosome segregation, DNA replication, repair, and recombination all act, not on DNA alone, but on the chromatin template. DNA methylation, along with histone lysine methylation, establishes the framework for long-term epigenetic maintenance. The discovery that enzymes can (re)organise chromatin into accessible and inaccessible configurations revealed epigenetic mechanisms that considerably extend the information potential of the genetic code. In mammals, heterochromatin is characterised by DNA methylation at CpG dinucleotides and methylation at lysine 9 of histone 3 (H3- K9), whereas euchromatin is associated with methylation at lysine 4 of histone 3 (H3-K4). In our experiments, the detection of DNA methylated regions at chromosomal level was performed using indirect immunofluorescence technique combined with FISH. (en)
Title	Cytological study of DNA methylation and histone methylation patterns in human cell lines Cytological study of DNA methylation and histone methylation patterns in human cell lines (en)
skos:prefLabel	Cytological study of DNA methylation and histone methylation patterns in human cell lines Cytological study of DNA methylation and histone methylation patterns in human cell lines (en)
skos:notation	RIV/00216224:14330/04:00009706!RIV11-AV0-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1A8241), P(GA202/04/0907), P(GP202/03/D033), P(IAA5004306), P(NC6987), Z(AV0Z5004920), Z(MSM 143300002)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kozubek, Michal Kozubek, Stanislav Skalníková, Magdalena
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	559212
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/04:00009706
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cytometry (en)
http://linked.open.../riv/klicoveSlovo	cytometry
http://linked.open...ontrolniKodProRIV	[A25BF72FDB56]
http://linked.open...v/mistoKonaniAkce	Brno
http://linked.open...i/riv/mistoVydani	Brno
http://linked.open...i/riv/nazevZdroje	Biophysics of the Genome
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	New possibilities of diagnostics of leukemia using DNA-microarrays Epigenetic control of gene expression in malignant diseases High-resolution cytomery of living cells The efect of methylation and acetylation on chromatin structure Human genome structure
http://linked.open...UplatneniVysledku	2004
http://linked.open...iv/tvurceVysledku	Bártová, Eva Kozubek, Stanislav Kozubek, Michal Skalníková, Magdalena
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2004-10-12 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20143300002
number of pages	4 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Masaryk University
https://schema.org/isbn	80-210-3560-9
http://localhost/t...ganizacniJednotka	14330

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