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rdf:type
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Description
| - Many aspects of plant development, including patterning and tropisms, are largely dependent on the asymmetric distribution of the plant signaling molecule auxin. Auxin transport inhibitors (ATIs), which interfere with directional auxin transport, have been essential tools in formulating this concept. However, despite the use of ATIs in plant research for many decades, the mechanism of ATI action has remained largely elusive. Using real-time live-cell microscopy, we show here that prominent ATIs such as 2,3,5-triiodobenzoic acid (TIBA) and 2-(1-pyrenoyl) benzoic acid (PBA) inhibit vesicle trafficking in plant, yeast, and mammalian cells. Effects on micropinocytosis, rab5-labeled endosomal motility at the periphery of HeLa cells and on fibroblast mobility indicate that ATIs influence actin cytoskeleton. Visualization of actin cytoskeleton dynamics in plants, yeast, and mammalian cells show that ATIs stabilize actin.
- Many aspects of plant development, including patterning and tropisms, are largely dependent on the asymmetric distribution of the plant signaling molecule auxin. Auxin transport inhibitors (ATIs), which interfere with directional auxin transport, have been essential tools in formulating this concept. However, despite the use of ATIs in plant research for many decades, the mechanism of ATI action has remained largely elusive. Using real-time live-cell microscopy, we show here that prominent ATIs such as 2,3,5-triiodobenzoic acid (TIBA) and 2-(1-pyrenoyl) benzoic acid (PBA) inhibit vesicle trafficking in plant, yeast, and mammalian cells. Effects on micropinocytosis, rab5-labeled endosomal motility at the periphery of HeLa cells and on fibroblast mobility indicate that ATIs influence actin cytoskeleton. Visualization of actin cytoskeleton dynamics in plants, yeast, and mammalian cells show that ATIs stabilize actin. (en)
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Title
| - Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes
- Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes (en)
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skos:prefLabel
| - Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes
- Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes (en)
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skos:notation
| - RIV/00216224:14310/08:00027622!RIV10-MSM-14310___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA204/05/0838), P(IAA601630703), P(KJB600380604), P(LC06034), Z(AV0Z50200510), Z(AV0Z50380511), Z(MSM0021622415)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/08:00027622
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - PIN proteins; plant development; vesicle traffic; auxin efflux inhibitors (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Proceedings of the National Academy of Sciences of the United States of America
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Friml, Jiří
- Petrášek, Jan
- Zažímalová, Eva
- Tejos, Ricardo
- Hašek, Jiří
- Seifertová, Daniela
- Akhmanova, Anna
- Brock, Roland
- Dhonukshe, Pankaj
- Fischer, Rainer
- Gadella, Jr, Theodorus W. J.
- Grigoriev, Ilya
- Meiselm, Lee A.
- Oiwa, Kazuhiro
- Paciorek, Tomasz
- Robinson, David G
- Spang, Anne
- Stierhof, York-Dieter
- Tominaga, Motoki
- Ueda, Takashi
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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