About: AhR-mediated and antiestrogenic activity of humic substances

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Humic substances (HS) were for decades regarded as inert in the ecosystems with respect to their possible toxicity. However, HS have been recently shown to elicit various adverse effects generally attributed to xenobiotics. In our study, we used MVLN and H4IIE-luc cell lines stably transfected with luciferase gene under control of estrogen receptor (ER) and Ah receptor (AhR; receptor connected with so-called dioxin-like toxicity) for assessment of anti/estrogenic and AhR-mediated effects of 12 commercially available humic substances. Out of those, five humic acids were shown to induce AhR-mediated activity with relative potencies related to TCDD 2.6 x 10-8-7.4 x 10-8. Organic extracts of HS solutions also elicited high activities what means that lipophilic molecules are responsible for a great part of effect. However, relatively high activity remaining in extracted solution suggests also presence of polar AhR-agonists. Humic substances (HS) were for decades regarded as inert in the ecosystems with respect to their possible toxicity. However, HS have been recently shown to elicit various adverse effects generally attributed to xenobiotics. In our study, we used MVLN and H4IIE-luc cell lines stably transfected with luciferase gene under control of estrogen receptor (ER) and Ah receptor (AhR; receptor connected with so-called dioxin-like toxicity) for assessment of anti/estrogenic and AhR-mediated effects of 12 commercially available humic substances. Out of those, five humic acids were shown to induce AhR-mediated activity with relative potencies related to TCDD 2.6 x 10-8-7.4 x 10-8. Organic extracts of HS solutions also elicited high activities what means that lipophilic molecules are responsible for a great part of effect. However, relatively high activity remaining in extracted solution suggests also presence of polar AhR-agonists. (en)
Title	AhR-mediated and antiestrogenic activity of humic substances AhR-mediated and antiestrogenic activity of humic substances (en)
skos:prefLabel	AhR-mediated and antiestrogenic activity of humic substances AhR-mediated and antiestrogenic activity of humic substances (en)
skos:notation	RIV/00216224:14310/07:00020344!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP525/05/P160), Z(MSM0021622412)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Bittner, Michal Bláha, Luděk Holoubek, Ivan Hilscherová, Klára Janošek, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	408796
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/07:00020344
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Ah receptor; AhR-mediated activity; Antiestrogenic effects; Endocrine disruption (en)
http://linked.open.../riv/klicoveSlovo	Endocrine disruption Ah receptor AhR-mediated activity Antiestrogenic effects
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[D855070859D3]
http://linked.open...i/riv/nazevZdroje	Chemosphere
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	67
http://linked.open...iv/tvurceVysledku	Bláha, Luděk Hilscherová, Klára Holoubek, Ivan Bittner, Michal Giesy, J. P. Janošek, Jaroslav
http://linked.open...ain/vavai/riv/wos	000245846700005
http://linked.open...n/vavai/riv/zamer	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)
issn	0045-6535
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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