About: Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors     Goto   Sponge   Distinct   Permalink

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Description
  • The title pyrazolo[1,5-a]pyrimidines [I; Q = SO2NR6R7, CONR6R7, CO2R7; R2 = (un)substituted alkyl, alkynyl, alkynylalkyl, cycloalkyl, CF3, CO2R6, aryl, arylalkyl, heteroarylalkyl, heterocyclyl, etc., wherein aryl is optionally substituted; R3 = H, halogen, NR5R6, CONR5R6, CO2R4, each (un)substituted alkyl, alkynyl, cycloalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl, etc.; R4 = H, halo, alkyl; R5 = H, alkyl; R6 = H, each (un)substituted alkyl, aryl, arylalkyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; R7 = each (un)substituted alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or R5 and R6 in the moiety -NR5R6, may be joined together to form an (un)substituted cycloalkyl or heterocyclyl] or pharmaceutically acceptable salts or solvates thereof are prepd. In its many embodiments, the present invention also provides methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds.
  • The title pyrazolo[1,5-a]pyrimidines [I; Q = SO2NR6R7, CONR6R7, CO2R7; R2 = (un)substituted alkyl, alkynyl, alkynylalkyl, cycloalkyl, CF3, CO2R6, aryl, arylalkyl, heteroarylalkyl, heterocyclyl, etc., wherein aryl is optionally substituted; R3 = H, halogen, NR5R6, CONR5R6, CO2R4, each (un)substituted alkyl, alkynyl, cycloalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl, etc.; R4 = H, halo, alkyl; R5 = H, alkyl; R6 = H, each (un)substituted alkyl, aryl, arylalkyl, cycloalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; R7 = each (un)substituted alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or R5 and R6 in the moiety -NR5R6, may be joined together to form an (un)substituted cycloalkyl or heterocyclyl] or pharmaceutically acceptable salts or solvates thereof are prepd. In its many embodiments, the present invention also provides methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds. (en)
Title
  • Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors
  • Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors (en)
skos:prefLabel
  • Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors
  • Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors (en)
skos:notation
  • RIV/00216224:14310/04:00035997!RIV10-MSM-14310___
http://linked.open...tracePatentuVzoru
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N
http://linked.open...cisloPatentuVzoru
  • WO 2004/022062 A1
http://linked.open...eleniPatentuVzoru
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 583273
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/04:00035997
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cyclin dependent kinase; inhibitor; pyrazolopyrimidine (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [BC93421B4746]
http://linked.open.../licencniPoplatek
http://linked.open...ydaniPatentuVzoru
  • USA
http://linked.open...atelePatentuVzoru
  • World Intellectual Property Organization
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...ydaniPatentuVzoru
http://linked.open...iv/tvurceVysledku
  • Dwyer, Michael
  • Guzi, Timothy
  • Paruch, Kamil
  • Doll, Ronald
  • James, Ray
  • Knutson, Chad
  • McKittrick, Brian
  • Park, Haengsoon
  • Girijavallabhan, Viyyoor
  • Dillard, Lawrence
  • He, Zhen
  • Tran, Vinh
http://linked.open...mniOchranaPatentu
http://linked.open...avai/riv/vlastnik
http://linked.open...itiJinymSubjektem
http://linked.open...uzitiPatentuVzoru
http://linked.open...stnikPatentuVzoru
  • Schering Plough; Pharmacopeia
http://localhost/t...ganizacniJednotka
  • 14310
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