About: Ribosomal RNA Kink-turn motif - a flexible molecular hinge     Goto   Sponge   Distinct   Permalink

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Description
  • Ribosomal RNA K-turn motifs are asymmetric internal loops characterized by a sharp bend in the phosphodiester backbone resulting in "V" shaped structures, recurrently observed in ribosomes and showing high degree of sequence conservation. We have carried out extended explicit solvent molecular dynamics simulations of selected K-turns, in order to investigate their intrinsic structural and dynamical properties. The simulations reveal an unprecedented dynamical flexibility of the K-turns around their x-ray geometries. The K-turns sample, on the nanosecond timescale, different conformational substates. The overall behaviour of the simulations suggests that the sampled geometries are essentially isoenergetic and separated by minimal energy barriers. The nanosecond dynamics of isolated K-turns can be qualitatively considered as motion of two rigid helix stems controlled by a very flexible internal loop which then leads to substantial hinge-like motions between the two stems. This internal dynamic
  • Ribosomal RNA K-turn motifs are asymmetric internal loops characterized by a sharp bend in the phosphodiester backbone resulting in "V" shaped structures, recurrently observed in ribosomes and showing high degree of sequence conservation. We have carried out extended explicit solvent molecular dynamics simulations of selected K-turns, in order to investigate their intrinsic structural and dynamical properties. The simulations reveal an unprecedented dynamical flexibility of the K-turns around their x-ray geometries. The K-turns sample, on the nanosecond timescale, different conformational substates. The overall behaviour of the simulations suggests that the sampled geometries are essentially isoenergetic and separated by minimal energy barriers. The nanosecond dynamics of isolated K-turns can be qualitatively considered as motion of two rigid helix stems controlled by a very flexible internal loop which then leads to substantial hinge-like motions between the two stems. This internal dynamic (en)
  • Ribosomal RNA K-turn motifs are asymmetric internal loops characterized by a sharp bend in the phosphodiester backbone resulting in "V" shaped structures, recurrently observed in ribosomes and showing high degree of sequence conservation. We have carried out extended explicit solvent molecular dynamics simulations of selected K-turns, in order to investigate their intrinsic structural and dynamical properties. The simulations reveal an unprecedented dynamical flexibility of the K-turns around their x-ray geometries. The K-turns sample, on the nanosecond timescale, different conformational substates. The overall behaviour of the simulations suggests that the sampled geometries are essentially isoenergetic and separated by minimal energy barriers. The nanosecond dynamics of isolated K-turns can be qualitatively considered as motion of two rigid helix stems controlled by a very flexible internal loop which then leads to substantial hinge-like motions between the two stems. This internal dynamic (cs)
Title
  • Ribosomal RNA Kink-turn motif - a flexible molecular hinge
  • Ribozomalny Kink-turn motiv - flexibilny molekularny klb (cs)
  • Ribosomal RNA Kink-turn motif - a flexible molecular hinge (en)
skos:prefLabel
  • Ribosomal RNA Kink-turn motif - a flexible molecular hinge
  • Ribozomalny Kink-turn motiv - flexibilny molekularny klb (cs)
  • Ribosomal RNA Kink-turn motif - a flexible molecular hinge (en)
skos:notation
  • RIV/00216224:14310/04:00021349!RIV08-MSM-14310___
http://linked.open.../vavai/riv/strany
  • 87-87
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(LN00A016)
http://linked.open...vai/riv/dodaniDat
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  • 584679
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/04:00021349
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Kink turn; RNA flexibility (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [F4E9567BFB44]
http://linked.open...v/mistoKonaniAkce
  • Jackson, MS, USA
http://linked.open...i/riv/mistoVydani
  • Jackson, MS, USA
http://linked.open...i/riv/nazevZdroje
  • Conference on Current Trends in Computational Chemistry
http://linked.open...in/vavai/riv/obor
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http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Koča, Jaroslav
  • Rázga, Filip
  • Réblová, Kamila
  • Šponer, Jiří
  • Leontis, Neocles B.
  • Špačková, Naděžda
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
number of pages
http://purl.org/ne...btex#hasPublisher
  • Jackson, Miss, USA
http://localhost/t...ganizacniJednotka
  • 14310
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