About: Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology

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About: Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The past decade has witnessed an explosion of knowledge concerning the structure and function of chromosome terminal structures-telomeres. Today's telomere research has advanced from a pure descriptive approach of DNA and protein components to an elementary understanding of telomere metabolism, and now to promising applications in medicine. These applications include 'passive' ones, among which the use of analysis of telomeres and telomerase for cancer diagnostics is the best known. The 'active' applications involve targeted downregulation or upregulation of telomere synthesis, either to mortalize immortal cancer cells, or to rejuvenate mortal somatic cells and tissues for cellular transplantations , respectively. The past decade has witnessed an explosion of knowledge concerning the structure and function of chromosome terminal structures-telomeres. Today's telomere research has advanced from a pure descriptive approach of DNA and protein components to an elementary understanding of telomere metabolism, and now to promising applications in medicine. These applications include 'passive' ones, among which the use of analysis of telomeres and telomerase for cancer diagnostics is the best known. The 'active' applications involve targeted downregulation or upregulation of telomere synthesis, either to mortalize immortal cancer cells, or to rejuvenate mortal somatic cells and tissues for cellular transplantations , respectively. (en) The past decade has witnessed an explosion of knowledge concerning the structure and function of chromosome terminal structures-telomeres. Today's telomere research has advanced from a pure descriptive approach of DNA and protein components to an elementary understanding of telomere metabolism, and now to promising applications in medicine. These applications include 'passive' ones, among which the use of analysis of telomeres and telomerase for cancer diagnostics is the best known. The 'active' applications involve targeted downregulation or upregulation of telomere synthesis, either to mortalize immortal cancer cells, or to rejuvenate mortal somatic cells and tissues for cellular transplantations , respectively. (cs)
Title	Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology (en) Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology (cs)
skos:prefLabel	Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology (en) Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology (cs)
skos:notation	RIV/00216224:14310/02:00006954!RIV09-GA0-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/99/0045), P(IBS5004010), Z(AV0Z5004920), Z(MSM 143100008)
http://linked.open...iv/cisloPeriodika	April
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Šimíčková, Marta Fajkus, Jiří Maláska, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	667044
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/02:00006954
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	human telomere; telomerase regulation; cancer; inhibiotin; cell engineering; tissue engineering (en)
http://linked.open.../riv/klicoveSlovo	tissue engineering cancer human telomere cell engineering inhibiotin telomerase regulation
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[924086FC4129]
http://linked.open...i/riv/nazevZdroje	Phil. Trans. R. Soc. Lond. B
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Telomere dynamics in selected types of solid malignant diseases Development of new diagnostic techniques for oncology
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	roč. 357
http://linked.open...iv/tvurceVysledku	Fajkus, Jiří Maláska, Jan Šimíčková, Marta
http://linked.open...ain/vavai/riv/wos	000175540200009
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20143100008
issn	0962-8436
number of pages	18 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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