About: Metabolic syndrome – dysregulation of adipose tissue endocrine function

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Metabolic syndrome, a condition increasing cardiovascular morbidity, mortality and risk for diabetes mellitus type 2, is currently worldwide reaching epidemic proportions. This complex disorder represents an urgent challenge for new pharmacotherapeutic strategies formulation. Pathophysiological mechanisms underlying metabolic syndrome are not completely understood, nevertheless growing evidence is supporting the hypothesis that multiple metabolic dysregulations do contribute to its development. A potential target for pharmacological intervention is considered to be dysregulation of adipose tissue endocrine/paracrine function. Specific adipokines, proteins secreted by the adipose tissue, with some pleiotropic effects, have been identified with strong association to regulation of energy metabolism, appetite, insulin signaling, tissue insulin sensitivity and the proinflammatory state related to metabolic syndrome. Metabolic syndrome, a condition increasing cardiovascular morbidity, mortality and risk for diabetes mellitus type 2, is currently worldwide reaching epidemic proportions. This complex disorder represents an urgent challenge for new pharmacotherapeutic strategies formulation. Pathophysiological mechanisms underlying metabolic syndrome are not completely understood, nevertheless growing evidence is supporting the hypothesis that multiple metabolic dysregulations do contribute to its development. A potential target for pharmacological intervention is considered to be dysregulation of adipose tissue endocrine/paracrine function. Specific adipokines, proteins secreted by the adipose tissue, with some pleiotropic effects, have been identified with strong association to regulation of energy metabolism, appetite, insulin signaling, tissue insulin sensitivity and the proinflammatory state related to metabolic syndrome. (en)
Title	Metabolic syndrome – dysregulation of adipose tissue endocrine function Metabolic syndrome – dysregulation of adipose tissue endocrine function (en)
skos:prefLabel	Metabolic syndrome – dysregulation of adipose tissue endocrine function Metabolic syndrome – dysregulation of adipose tissue endocrine function (en)
skos:notation	RIV/00216224:14110/14:00076563!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita	P S V
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), S, V
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Kučerová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	28528
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/14:00076563
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	metabolic syndrome; insulin resistance; adipose tissue; adipokines (en)
http://linked.open.../riv/klicoveSlovo	adipokines adipose tissue insulin resistance metabolic syndrome
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[B160E37872EA]
http://linked.open...i/riv/nazevZdroje	Česká a slovenská farmacie
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	63
http://linked.open...iv/tvurceVysledku	Kučerová, Jana Suchý, Pavel Horská, Kateřina Kotolová, Hana
issn	1210-7816
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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