About: Quantitative detection of an IDH2 mutation for minimal residual disease monitoring in acute myeloid leukemia patients and its comparison with mutations in the NPM1 gene     Goto   Sponge   Distinct   Permalink

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  • Acquired mutations in the IDH1 and IDH2 genes have been detected in various hematological disorders, including acute myeloid leukemia (AML), where the incidence has been reported to be 15%. The IDH1 and IDH2 genes encode enzymes that catalyze oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG). Somatic mutations cause their dysfunction and an accumulation of aberrant 2-hydroxygluterate (2-HG) product in cells. The decreased supply of alpha-KG or increased accumulation of 2-HG (i.e. metabolic biomarker of mutant IDH1/2 enzyme activity) is considered to be a possible basis for the oncogenic properties of IDH mutants.
  • Acquired mutations in the IDH1 and IDH2 genes have been detected in various hematological disorders, including acute myeloid leukemia (AML), where the incidence has been reported to be 15%. The IDH1 and IDH2 genes encode enzymes that catalyze oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG). Somatic mutations cause their dysfunction and an accumulation of aberrant 2-hydroxygluterate (2-HG) product in cells. The decreased supply of alpha-KG or increased accumulation of 2-HG (i.e. metabolic biomarker of mutant IDH1/2 enzyme activity) is considered to be a possible basis for the oncogenic properties of IDH mutants. (en)
Title
  • Quantitative detection of an IDH2 mutation for minimal residual disease monitoring in acute myeloid leukemia patients and its comparison with mutations in the NPM1 gene
  • Quantitative detection of an IDH2 mutation for minimal residual disease monitoring in acute myeloid leukemia patients and its comparison with mutations in the NPM1 gene (en)
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  • Quantitative detection of an IDH2 mutation for minimal residual disease monitoring in acute myeloid leukemia patients and its comparison with mutations in the NPM1 gene
  • Quantitative detection of an IDH2 mutation for minimal residual disease monitoring in acute myeloid leukemia patients and its comparison with mutations in the NPM1 gene (en)
skos:notation
  • RIV/00216224:14110/13:00067476!RIV14-MSM-14110___
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  • RIV/00216224:14110/13:00067476
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  • PROGNOSIS; FREQUENT (en)
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  • GB - Spojené království Velké Británie a Severního Irska
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  • [4C6EC45B7FEA]
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  • Leukemia & Lymphoma
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  • 54
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  • Dvořáková, Dana
  • Mayer, Jiří
  • Rázga, Filip
  • Ráčil, Zdeněk
  • Tošková, Martina
  • Ježíšková, Ivana
  • Timilsina, Shira
http://linked.open...ain/vavai/riv/wos
  • 000315898100032
issn
  • 1042-8194
number of pages
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  • 10.3109/10428194.2012.727414
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  • 14110
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