About: IDH2 mutations in patients with acute myeloid leukemia: missense p.R140 mutations are linked to disease status     Goto   Sponge   Distinct   Permalink

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  • In conclusion, our data demonstrate that, within the cohort of tested individuals, the IDH2 mutations are associated with AML (in contrast to healthy volunteers), suggesting a role for these mutations in disease pathogenesis. In addition, we show an association of the observed IDH2 mutations with disease status, indicating their potential for MRD monitoring. This report thus indicates that IDH2 p.R140 variants are possible markers for MRD detection. However, an extended investigation of IDH2 mutations kinetics, involving long-term followup and a larger cohort of IDH2 mutated AMLs, will be required to confirm these findings.
  • In conclusion, our data demonstrate that, within the cohort of tested individuals, the IDH2 mutations are associated with AML (in contrast to healthy volunteers), suggesting a role for these mutations in disease pathogenesis. In addition, we show an association of the observed IDH2 mutations with disease status, indicating their potential for MRD monitoring. This report thus indicates that IDH2 p.R140 variants are possible markers for MRD detection. However, an extended investigation of IDH2 mutations kinetics, involving long-term followup and a larger cohort of IDH2 mutated AMLs, will be required to confirm these findings. (en)
Title
  • IDH2 mutations in patients with acute myeloid leukemia: missense p.R140 mutations are linked to disease status
  • IDH2 mutations in patients with acute myeloid leukemia: missense p.R140 mutations are linked to disease status (en)
skos:prefLabel
  • IDH2 mutations in patients with acute myeloid leukemia: missense p.R140 mutations are linked to disease status
  • IDH2 mutations in patients with acute myeloid leukemia: missense p.R140 mutations are linked to disease status (en)
skos:notation
  • RIV/00216224:14110/10:00067242!RIV14-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 262800
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/10:00067242
http://linked.open...riv/jazykVysledku
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  • acute myeloid leukemia (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [8FB73447FBF6]
http://linked.open...i/riv/nazevZdroje
  • Leukemia & Lymphoma
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 51
http://linked.open...iv/tvurceVysledku
  • Dvořáková, Dana
  • Mayer, Jiří
  • Rázga, Filip
  • Ráčil, Zdeněk
  • Ježíšková, Ivana
  • Bajerová, Monika
http://linked.open...ain/vavai/riv/wos
  • 000285004300021
issn
  • 1042-8194
number of pages
http://bibframe.org/vocab/doi
  • 10.3109/10428194.2010.523126
http://localhost/t...ganizacniJednotka
  • 14110
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