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  • In recent years, several independent prognostic factors in cytogenetically normal acute myeloid leukemia (CN-AML) have been reported. Mutations or the expression levels of certatin genes have been often used as molecular markers for preidiction of a patients outcome or for evaluation of treatment outcome. One of them, the gene encoding CCAAT/enhanced binding protein alpha (CEBPA), plays an important role in myeloid differentiation and, whn mutated, confers a favorable prognosis for patients with CN-AML. Complete mutation screening of the CEBPA gene is therefore beneficial and requires fast, precise, and sensitive diagnostic tools. Thus, for routine diagnostics, we developed a screening method using high-resolution melt curve analysis prior to direct sequencing, where only positive samples (according to reference) are further sequenced.
  • In recent years, several independent prognostic factors in cytogenetically normal acute myeloid leukemia (CN-AML) have been reported. Mutations or the expression levels of certatin genes have been often used as molecular markers for preidiction of a patients outcome or for evaluation of treatment outcome. One of them, the gene encoding CCAAT/enhanced binding protein alpha (CEBPA), plays an important role in myeloid differentiation and, whn mutated, confers a favorable prognosis for patients with CN-AML. Complete mutation screening of the CEBPA gene is therefore beneficial and requires fast, precise, and sensitive diagnostic tools. Thus, for routine diagnostics, we developed a screening method using high-resolution melt curve analysis prior to direct sequencing, where only positive samples (according to reference) are further sequenced. (en)
Title
  • CEBPA Gene mutational status A complete screening using high-resolution melt curve analysis
  • CEBPA Gene mutational status A complete screening using high-resolution melt curve analysis (en)
skos:prefLabel
  • CEBPA Gene mutational status A complete screening using high-resolution melt curve analysis
  • CEBPA Gene mutational status A complete screening using high-resolution melt curve analysis (en)
skos:notation
  • RIV/00216224:14110/09:00036369!RIV11-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V, Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 306192
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/09:00036369
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • acute myeloid leukemia; CEBPA mutation (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [EAB069696207]
http://linked.open...i/riv/nazevZdroje
  • Molecular diagnosis and therapy
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 13
http://linked.open...iv/tvurceVysledku
  • Dvořáková, Dana
  • Jurček, Tomáš
  • Mayer, Jiří
  • Rázga, Filip
  • Ježíšková, Ivana
  • Křístková, Zlatuše
http://linked.open...ain/vavai/riv/wos
  • 000269290600004
http://linked.open...n/vavai/riv/zamer
issn
  • 1177-1062
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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