About: MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtype.

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About: MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtype. Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	MicroRNAs (miRNAs) are short, non-coding RNAs, which function as evolutionary conserved regulators of a gene expression. They have essential roles in development, cell differentiation, proliferation, apoptosis and chromosome structure. MiRNAs constitute about 3-5% of predicted genes in the human genome (i.e. about 1000); and 20-30% of the protein-coding genes are estimated to be regulated by the miRNAs. The primary evidence that miRNAs possibly act as a novel class of oncogenes/tumor-suppressors comes from the discovery of the miR-15a and miR-16-1 in 13q14 region deleted in chronic lymphocytic leukemia (CLL). Moreover, miRNA signatures have been used to classify tumor types. There have recently been several reports on the miRNAs role in CLL pathogenesis and disease subtypes (according to IgVH mutation status). In this report, we will review the published observations and present our miRNA profiling data in aggressive CLL with TP53 abnormalities (deletion and/or mutation of p53 gene). MicroRNAs (miRNAs) are short, non-coding RNAs, which function as evolutionary conserved regulators of a gene expression. They have essential roles in development, cell differentiation, proliferation, apoptosis and chromosome structure. MiRNAs constitute about 3-5% of predicted genes in the human genome (i.e. about 1000); and 20-30% of the protein-coding genes are estimated to be regulated by the miRNAs. The primary evidence that miRNAs possibly act as a novel class of oncogenes/tumor-suppressors comes from the discovery of the miR-15a and miR-16-1 in 13q14 region deleted in chronic lymphocytic leukemia (CLL). Moreover, miRNA signatures have been used to classify tumor types. There have recently been several reports on the miRNAs role in CLL pathogenesis and disease subtypes (according to IgVH mutation status). In this report, we will review the published observations and present our miRNA profiling data in aggressive CLL with TP53 abnormalities (deletion and/or mutation of p53 gene). (en)
Title	MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtype. MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtype. (en)
skos:prefLabel	MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtype. MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtype. (en)
skos:notation	RIV/00216224:14110/09:00035765!RIV11-MZ0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR9293), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Mráz, Marek Pospíšilová, Šárka Mayer, Jiří Šlapák, Ivo Plevová, Karla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	326207
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/09:00035765
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CLL; p53; miR-34a; miR-29c; miR-17-5p (en)
http://linked.open.../riv/klicoveSlovo	p53 miR-34a CLL miR-17-5p miR-29c
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[6AA9A1EFEF98]
http://linked.open...i/riv/nazevZdroje	LEUKEMIA & LYMPHOMA
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Application of MicroRNAs and Small Interfering RNAs in Diagnostics and Treatment of Leukemia
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	50
http://linked.open...iv/tvurceVysledku	Mayer, Jiří Mráz, Marek Pospíšilová, Šárka Šlapák, Ivo Plevová, Karla
http://linked.open...ain/vavai/riv/wos	000265361100040
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	1042-8194
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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